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| Presentation | 2007-06-14 11:45 A Study on Significance Analysis of Gene Sets Using Nearest-Neighbor Classification Error Ichiro Takeuchi, Shintaro Hayashi (Mie Univ.), Miyuki Suguro, Masao Seto (Aichi Cancer Center)  NC2007-13 |
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| Abstract | (in Japanese) | (See Japanese page) |
| (in English) | Relating gene expression profiles from microarray experiments with biological knowledge databases is an important step for understanding biological mechanism. It motivates the development of statistical techniques that quantify the significance of the expression profiles for sets of genes defined, e.g., based on pathway information. In this report we propose a new approach for gene set significance analysis. The proposed test measures the significance of gene sets using cross-validated errors of nearest-neighbor classifiers. Our approach is computationally efficient and powerful to detect various types of differences in expression patterns. We demonstrate the advantage of our approach through the simulation studies for power analysis and an application to a public microarray data. | |
| Keyword | (in Japanese) | (See Japanese page) |
| (in English) | Microarray / Expression Profile / Pathway Analysis / Gene Set / Statistical Test / Multiple Comparison / Permutation Test / Nearest-Neighbor Method | |
| Reference Info. | IEICE Tech. Rep., vol. 107, no. 92, NC2007-13, pp. 29-34, June 2007. | |
| Paper # | NC2007-13 | |
| Date of Issue | 2007-06-07 (NC) | |
| ISSN | Print edition: ISSN 0913-5685 Online edition: ISSN 2432-6380 | |
| Copyright and reproduction |
All rights are reserved and no part of this publication may be reproduced or transmitted in any form or by any means, electronic or mechanical, including photocopy, recording, or any information storage and retrieval system, without permission in writing from the publisher. Notwithstanding, instructors are permitted to photocopy isolated articles for noncommercial classroom use without fee. (License No.: 10GA0019/12GB0052/13GB0056/17GB0034/18GB0034) | |
| Download PDF | NC2007-13 |
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| Conference Information | |
| Committee | NC |
| Conference Date | 2007-06-14 - 2007-06-15 |
| Place (in Japanese) | (See Japanese page) |
| Place (in English) | OIST Seaside House |
| Topics (in Japanese) | (See Japanese page) |
| Topics (in English) | |
| Paper Information | |
| Registration To | NC |
| Conference Code | 2007-06-NC |
| Language | Japanese |
| Title (in Japanese) | (See Japanese page) |
| Sub Title (in Japanese) | (See Japanese page) |
| Title (in English) | A Study on Significance Analysis of Gene Sets Using Nearest-Neighbor Classification Error |
| Sub Title (in English) | |
| Keyword(1) | Microarray |
| Keyword(2) | Expression Profile |
| Keyword(3) | Pathway Analysis |
| Keyword(4) | Gene Set |
| Keyword(5) | Statistical Test |
| Keyword(6) | Multiple Comparison |
| Keyword(7) | Permutation Test |
| Keyword(8) | Nearest-Neighbor Method |
| 1st Author's Name | Ichiro Takeuchi |
| 1st Author's Affiliation | Mie University (Mie Univ.) |
| 2nd Author's Name | Shintaro Hayashi |
| 2nd Author's Affiliation | Mie University (Mie Univ.) |
| 3rd Author's Name | Miyuki Suguro |
| 3rd Author's Affiliation | Aichi Cancer Center (Aichi Cancer Center) |
| 4th Author's Name | Masao Seto |
| 4th Author's Affiliation | Aichi Cancer Center (Aichi Cancer Center) |
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| Speaker | Author-1 |
| Date Time | 2007-06-14 11:45:00 |
| Presentation Time | 25 minutes |
| Registration for | NC |
| Paper # | NC2007-13 |
| Volume (vol) | vol.107 |
| Number (no) | no.92 |
| Page | pp.29-34 |
| #Pages | 6 |
| Date of Issue | 2007-06-07 (NC) |
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