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Paper Abstract and Keywords
Presentation 2007-06-14 11:45
A Study on Significance Analysis of Gene Sets Using Nearest-Neighbor Classification Error
Ichiro Takeuchi, Shintaro Hayashi (Mie Univ.), Miyuki Suguro, Masao Seto (Aichi Cancer Center) NC2007-13
Abstract (in Japanese) (See Japanese page) 
(in English) Relating gene expression profiles from microarray experiments with biological knowledge databases is an important step for understanding biological mechanism. It motivates the development of statistical techniques that quantify the significance of the expression profiles for sets of genes defined, e.g., based on pathway information. In this report we propose a new approach for gene set significance analysis. The proposed test measures the significance of gene sets using cross-validated errors of nearest-neighbor classifiers. Our approach is computationally efficient and powerful to detect various types of differences in expression patterns. We demonstrate the advantage of our approach through the simulation studies for power analysis and an application to a public microarray data.
Keyword (in Japanese) (See Japanese page) 
(in English) Microarray / Expression Profile / Pathway Analysis / Gene Set / Statistical Test / Multiple Comparison / Permutation Test / Nearest-Neighbor Method  
Reference Info. IEICE Tech. Rep., vol. 107, no. 92, NC2007-13, pp. 29-34, June 2007.
Paper # NC2007-13 
Date of Issue 2007-06-07 (NC) 
ISSN Print edition: ISSN 0913-5685    Online edition: ISSN 2432-6380
All rights are reserved and no part of this publication may be reproduced or transmitted in any form or by any means, electronic or mechanical, including photocopy, recording, or any information storage and retrieval system, without permission in writing from the publisher. Notwithstanding, instructors are permitted to photocopy isolated articles for noncommercial classroom use without fee. (License No.: 10GA0019/12GB0052/13GB0056/17GB0034/18GB0034)
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Conference Information
Committee NC  
Conference Date 2007-06-14 - 2007-06-15 
Place (in Japanese) (See Japanese page) 
Place (in English) OIST Seaside House 
Topics (in Japanese) (See Japanese page) 
Topics (in English)  
Paper Information
Registration To NC 
Conference Code 2007-06-NC 
Language Japanese 
Title (in Japanese) (See Japanese page) 
Sub Title (in Japanese) (See Japanese page) 
Title (in English) A Study on Significance Analysis of Gene Sets Using Nearest-Neighbor Classification Error 
Sub Title (in English)  
Keyword(1) Microarray  
Keyword(2) Expression Profile  
Keyword(3) Pathway Analysis  
Keyword(4) Gene Set  
Keyword(5) Statistical Test  
Keyword(6) Multiple Comparison  
Keyword(7) Permutation Test  
Keyword(8) Nearest-Neighbor Method  
1st Author's Name Ichiro Takeuchi  
1st Author's Affiliation Mie University (Mie Univ.)
2nd Author's Name Shintaro Hayashi  
2nd Author's Affiliation Mie University (Mie Univ.)
3rd Author's Name Miyuki Suguro  
3rd Author's Affiliation Aichi Cancer Center (Aichi Cancer Center)
4th Author's Name Masao Seto  
4th Author's Affiliation Aichi Cancer Center (Aichi Cancer Center)
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Date Time 2007-06-14 11:45:00 
Presentation Time 25 minutes 
Registration for NC 
Paper # NC2007-13 
Volume (vol) vol.107 
Number (no) no.92 
Page pp.29-34 
Date of Issue 2007-06-07 (NC) 

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