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| Presentation | 2009-01-19 10:30 [Special Invited Talk] Molecular Imaging at National Taiwan University Pai-Chi Li (National Taiwan Univ.)  MI2008-56 |
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| Abstract | (in Japanese) | (See Japanese page) |
| (in English) | Molecular imaging has attracted widespread research attention. It can be generally defined as any measurement of events occurring at the molecular level in a spatially and temporally resolved manner. In other words, it is the characterization and measurements of biological processes in living animals, model systems, and humans at the molecular level using remote imaging detectors. Recent interest in the development of novel strategies for the production of nanoparticles also helps accelerate the development of molecular imaging and it is being pursued in all areas of noninvasive medical imaging, including nuclear medicine, magnetic resonance imaging, ultrasound and optics. Each imaging modality has unique advantages and disadvantages, and ultimately the best approach is dependent upon the question being addressed. It is important to note that one major premise of molecular imaging is that it is not defined by the imaging technologies that underpin acquisition of the final image, but rather is driven by the underlying biological questions. In this talk, we will overview the research activities of molecular imaging at National Taiwan University. In addition to a general introduction, recent development of ultrasonic molecular imaging and photoacoustic molecular imaging will also be specifically described. Ultrasonic imaging and photoacoustic imaging provide unique advantages and also face specific challenges. Ultrasonic molecular imaging, on one hand, is based on mechanical properties of the image object and many unique applications have been developed. With the aid of superior spatial resolution, high frequency ultrasound imaging has also evolved from clinical anatomical imaging to probing of molecular processes on small animals for pre-clinical research. Photoacoustic imaging, on the other hand, combines advantages of both optics and acoustics. Research developments in imaging physics and instrumentation have also found promising biomedical applications. In addition, microbubbles typically used in ultrasonic imaging as the contrast agent present unique mechanical properties and the associated acoustic cavitation has been exploited for therapeutic purposes. Similarly, gold nanoparticles are found to be an ideal contrast agent for photoacoustic imaging for its bioconjugation capabilities and presumed safety. The efficient light absorption of gold nanoparticles and abilities to tune their optical properties have also led to new photothermal therapy techniques. We will review our efforts in physics, instrumentation and applications of ultrasonic and photoacoustic imaging. New development in combined diagnosis with therapy for both modalities will also be introduced, with a discussion on possible synergy and the technical difficulties that each modality faces, before critical clinical impact can be made. |
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| Keyword | (in Japanese) | (See Japanese page) |
| (in English) | molecular imaging / National Taiwan University / ultrasonic imaging / photoacoustic imaging / / / / | |
| Reference Info. | IEICE Tech. Rep., vol. 108, no. 385, MI2008-56, pp. 3-3, Jan. 2009. | |
| Paper # | MI2008-56 | |
| Date of Issue | 2009-01-12 (MI) | |
| ISSN | Print edition: ISSN 0913-5685 Online edition: ISSN 2432-6380 | |
| Copyright and reproduction |
All rights are reserved and no part of this publication may be reproduced or transmitted in any form or by any means, electronic or mechanical, including photocopy, recording, or any information storage and retrieval system, without permission in writing from the publisher. Notwithstanding, instructors are permitted to photocopy isolated articles for noncommercial classroom use without fee. (License No.: 10GA0019/12GB0052/13GB0056/17GB0034/18GB0034) | |
| Download PDF | MI2008-56 |
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| Conference Information | |
| Committee | MI |
| Conference Date | 2009-01-19 - 2009-01-21 |
| Place (in Japanese) | (See Japanese page) |
| Place (in English) | National Taiwan University |
| Topics (in Japanese) | (See Japanese page) |
| Topics (in English) | Medical Imaging |
| Paper Information | |
| Registration To | MI |
| Conference Code | 2009-01-MI |
| Language | English |
| Title (in Japanese) | (See Japanese page) |
| Sub Title (in Japanese) | (See Japanese page) |
| Title (in English) | Molecular Imaging at National Taiwan University |
| Sub Title (in English) | |
| Keyword(1) | molecular imaging |
| Keyword(2) | National Taiwan University |
| Keyword(3) | ultrasonic imaging |
| Keyword(4) | photoacoustic imaging |
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| 1st Author's Name | Pai-Chi Li |
| 1st Author's Affiliation | National Taiwan University (National Taiwan Univ.) |
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| Speaker | Author-1 |
| Date Time | 2009-01-19 10:30:00 |
| Presentation Time | 20 minutes |
| Registration for | MI |
| Paper # | MI2008-56 |
| Volume (vol) | vol.108 |
| Number (no) | no.385 |
| Page | p.3 |
| #Pages | 1 |
| Date of Issue | 2009-01-12 (MI) |
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