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Paper Abstract and Keywords
Presentation 2009-03-11 13:55
Estimation of Intracellular Calcium Ion Concentration by Non-Linear State Space Modeling
Takamasa Tsunoda (Tokyo Inst. of Tech.), Toshiaki Omori (univ. of tokyo/RIKEN Brain Sci Inst.), Hiroyoshi Miyakawa (Tokyo Univ. of Phar and Life Sci.), Masato Okada (univ. of tokyo/RIKEN Brain Sci Inst.), Toru Aonishi (Tokyo Inst. of Tech./RIKEN Brain Sci Inst.) NC2008-107
Abstract (in Japanese) (See Japanese page) 
(in English) The ionic dynamics depending on the nervous activity recently attracts attentions of many researchers due to the rapid progress of Ion-Imaging techniques.
However, there are several problems to be addressed in the ion-imaging techniques.
In this paper, we developed statistical estimation methods for calcium ion dynamics from noisy fluoresce signals. First, we composed a state-space model describing calcium ion inflow kinetics, binding kinetics of calcium buffers and calcium indicators, and optical measuring devices for detecting fluorescent signals.
Then, we derived an algorithm based on the belief propagation method for estimating calcium ion concentrations, and the EM algorithm for estimating model parameters.
We numerically verified the efficacy of our algorithms by applying to artificial data. Our algorithm proposed here makes it possible to estimate not only intracellular calcium ion concentration but also calcium ion inflow through the cell membrane and Endoplasmic Reticula (ER) membrane et al.
It is expected that the understanding for the molecular mechanisms such as the calcium channels and Ca store can be promoted by our method, since variation of calcium inflows give the significant information these molecular mechanisms.
Keyword (in Japanese) (See Japanese page) 
(in English) intracellular calcium-ion concentration / Calcium imaging / Nonlinear state-space model / Belief propagation / EM algorithm / / /  
Reference Info. IEICE Tech. Rep., vol. 108, no. 480, NC2008-107, pp. 25-30, March 2009.
Paper # NC2008-107 
Date of Issue 2009-03-04 (NC) 
ISSN Print edition: ISSN 0913-5685    Online edition: ISSN 2432-6380
All rights are reserved and no part of this publication may be reproduced or transmitted in any form or by any means, electronic or mechanical, including photocopy, recording, or any information storage and retrieval system, without permission in writing from the publisher. Notwithstanding, instructors are permitted to photocopy isolated articles for noncommercial classroom use without fee. (License No.: 10GA0019/12GB0052/13GB0056/17GB0034/18GB0034)
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Conference Information
Committee NC MBE  
Conference Date 2009-03-11 - 2009-03-13 
Place (in Japanese) (See Japanese page) 
Place (in English) Tamagawa Univ. 
Topics (in Japanese) (See Japanese page) 
Topics (in English)  
Paper Information
Registration To NC 
Conference Code 2009-03-NC-MBE 
Language Japanese 
Title (in Japanese) (See Japanese page) 
Sub Title (in Japanese) (See Japanese page) 
Title (in English) Estimation of Intracellular Calcium Ion Concentration by Non-Linear State Space Modeling 
Sub Title (in English)  
Keyword(1) intracellular calcium-ion concentration  
Keyword(2) Calcium imaging  
Keyword(3) Nonlinear state-space model  
Keyword(4) Belief propagation  
Keyword(5) EM algorithm  
1st Author's Name Takamasa Tsunoda  
1st Author's Affiliation Tokyo Institute of Technology (Tokyo Inst. of Tech.)
2nd Author's Name Toshiaki Omori  
2nd Author's Affiliation The university of tokyo/RIKEN Brain Science Institute (univ. of tokyo/RIKEN Brain Sci Inst.)
3rd Author's Name Hiroyoshi Miyakawa  
3rd Author's Affiliation Tokyo University of Pharmacy and Life Sciencess (Tokyo Univ. of Phar and Life Sci.)
4th Author's Name Masato Okada  
4th Author's Affiliation The university of tokyo/RIKEN Brain Science Institute (univ. of tokyo/RIKEN Brain Sci Inst.)
5th Author's Name Toru Aonishi  
5th Author's Affiliation Tokyo Institute of Technology/RIKEN Brain Science Institute (Tokyo Inst. of Tech./RIKEN Brain Sci Inst.)
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Speaker Author-1 
Date Time 2009-03-11 13:55:00 
Presentation Time 25 minutes 
Registration for NC 
Paper # NC2008-107 
Volume (vol) vol.108 
Number (no) no.480 
Page pp.25-30 
Date of Issue 2009-03-04 (NC) 

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