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Paper Abstract and Keywords
Presentation 2011-01-20 10:15
Preliminary study of in-vivo liver measurement by optimized pulse sequence for MR elastography
Ken Arai (Chiba Univ.), Mikio Suga (Chiba Univ./NIRS), Shinya Ozawa, Hajime Ikeda (Chiba Univ.), Masaya Hirano (GEHC-JP), Etsuko Kobayashi (Tokyo Univ.), Takayuki Obata (NIRS) MI2010-89
Abstract (in Japanese) (See Japanese page) 
(in English) Magnetic resonance elastography (MRE) is a technique for quantitative and noninvasive assessment of tissue elasticity. MRE is often described as image-based palpation that can be used to characterize disease because the mechanical properties of tissues are often dramatically affected by the presence of disease processes. MRE pulse sequences obtain shear wave images by synchronizing motion sensitized gradients (MSG) with an external vibrator. A quantitative shear modulus map is calculated from the shear wave images. However, the magnitude property of the external vibrator and nonlinearity of the imaged object often induce unwanted higher harmonics that distort the shear wave images and impair the estimation of the elastic modulus. Additionally, bulk motion can induce signal loss, ghosting and unwanted phase accumulation. In this study, we apply the MSGs to gradient moment nulling (GMN) technique for reducing bulk motion effect and optimize them to minimize the contribution of higher harmonics to the shear wave images and therefore improve the accuracy of shear modulus estimation. Phantom and in-vivo study was performed to confirm the performance of the proposed MRE pulse sequence. The results show that the optimized MSG is able to acquire single frequency shear wave images even when large amplitude harmonic waves are present in the imaged object. Additionally, the proposed MRE pulse sequence reduced cardiac motion artifact. These results suggest that the proposed pulse sequence might be useful for in-vivo MRE studies.
Keyword (in Japanese) (See Japanese page) 
(in English) MR elastography / pulse sequence / motion sensitizing gradients (MSG) / shear modulus measurement / MRI / / /  
Reference Info. IEICE Tech. Rep., vol. 110, no. 364, MI2010-89, pp. 47-50, Jan. 2011.
Paper # MI2010-89 
Date of Issue 2011-01-12 (MI) 
ISSN Print edition: ISSN 0913-5685    Online edition: ISSN 2432-6380
All rights are reserved and no part of this publication may be reproduced or transmitted in any form or by any means, electronic or mechanical, including photocopy, recording, or any information storage and retrieval system, without permission in writing from the publisher. Notwithstanding, instructors are permitted to photocopy isolated articles for noncommercial classroom use without fee. (License No.: 10GA0019/12GB0052/13GB0056/17GB0034/18GB0034)
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Conference Information
Committee MI  
Conference Date 2011-01-19 - 2011-01-20 
Place (in Japanese) (See Japanese page) 
Place (in English) Naha-Bunka-Tembusu 
Topics (in Japanese) (See Japanese page) 
Topics (in English) General Medical Imaging 
Paper Information
Registration To MI 
Conference Code 2011-01-MI 
Language Japanese 
Title (in Japanese) (See Japanese page) 
Sub Title (in Japanese) (See Japanese page) 
Title (in English) Preliminary study of in-vivo liver measurement by optimized pulse sequence for MR elastography 
Sub Title (in English)  
Keyword(1) MR elastography  
Keyword(2) pulse sequence  
Keyword(3) motion sensitizing gradients (MSG)  
Keyword(4) shear modulus measurement  
Keyword(5) MRI  
1st Author's Name Ken Arai  
1st Author's Affiliation Chiba University (Chiba Univ.)
2nd Author's Name Mikio Suga  
2nd Author's Affiliation Chiba University/National Institute of Radiological Sciences (Chiba Univ./NIRS)
3rd Author's Name Shinya Ozawa  
3rd Author's Affiliation Chiba University (Chiba Univ.)
4th Author's Name Hajime Ikeda  
4th Author's Affiliation Chiba University (Chiba Univ.)
5th Author's Name Masaya Hirano  
5th Author's Affiliation GE Healthcare Japan Corpolation (GEHC-JP)
6th Author's Name Etsuko Kobayashi  
6th Author's Affiliation Tokyo University (Tokyo Univ.)
7th Author's Name Takayuki Obata  
7th Author's Affiliation National Institute of Radiological Sciences (NIRS)
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Speaker Author-1 
Date Time 2011-01-20 10:15:00 
Presentation Time 15 minutes 
Registration for MI 
Paper # MI2010-89 
Volume (vol) vol.110 
Number (no) no.364 
Page pp.47-50 
Date of Issue 2011-01-12 (MI) 

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