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Paper Abstract and Keywords
Presentation 2012-05-25 11:55
Detection of change in mechanical properties of a single DNA molecule stretched by dual trap optical tweezers
Yoshihiro Murayama, Yusuke Yogiashi, Takuya Iwamoto (Tokyo Univ. of Agri. and Tech.) LQE2012-6 Link to ES Tech. Rep. Archives: LQE2012-6
Abstract (in Japanese) (See Japanese page) 
(in English) When DNA is stretched by dual trap optical tweezers, we can obtain not only force but also local spring constant of a single DNA by calculating auto-correlation and cross correlation of the fluctuation of attached beads. To apply the correlation methods to detect DNA-protein interaction without labeling, we investigated the appropriate condition of experimental setup and its ability for detection. We varied laser power and local spring constant of a stretched DNA, k_DNA, was obtained by using the correlation method at each laser power.
The results show that appropriate spring constant of optical tweezers is 4--5 pN/μm for our setup, and we can detect the change of k_DNA with 0.4 pN/μm accuracy, with the time resolution of 1 s.
Keyword (in Japanese) (See Japanese page) 
(in English) optical tweezers / DNA / mechanical properties / correlation function / / / /  
Reference Info. IEICE Tech. Rep., vol. 112, no. 62, LQE2012-6, pp. 25-28, May 2012.
Paper # LQE2012-6 
Date of Issue 2012-05-18 (LQE) 
ISSN Print edition: ISSN 0913-5685    Online edition: ISSN 2432-6380
Copyright
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reproduction
All rights are reserved and no part of this publication may be reproduced or transmitted in any form or by any means, electronic or mechanical, including photocopy, recording, or any information storage and retrieval system, without permission in writing from the publisher. Notwithstanding, instructors are permitted to photocopy isolated articles for noncommercial classroom use without fee. (License No.: 10GA0019/12GB0052/13GB0056/17GB0034/18GB0034)
Download PDF LQE2012-6 Link to ES Tech. Rep. Archives: LQE2012-6

Conference Information
Committee LQE LSJ  
Conference Date 2012-05-25 - 2012-05-25 
Place (in Japanese) (See Japanese page) 
Place (in English) Univ. of Fukui (Bunkyo Campus) 
Topics (in Japanese) (See Japanese page) 
Topics (in English) Quantum optics, nonlinear optics, ultra-high speed phenomenon, etc. 
Paper Information
Registration To LQE 
Conference Code 2012-05-LQE-LSJ 
Language Japanese 
Title (in Japanese) (See Japanese page) 
Sub Title (in Japanese) (See Japanese page) 
Title (in English) Detection of change in mechanical properties of a single DNA molecule stretched by dual trap optical tweezers 
Sub Title (in English)  
Keyword(1) optical tweezers  
Keyword(2) DNA  
Keyword(3) mechanical properties  
Keyword(4) correlation function  
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1st Author's Name Yoshihiro Murayama  
1st Author's Affiliation Tokyo University of Agriculture and Technology (Tokyo Univ. of Agri. and Tech.)
2nd Author's Name Yusuke Yogiashi  
2nd Author's Affiliation Tokyo University of Agriculture and Technology (Tokyo Univ. of Agri. and Tech.)
3rd Author's Name Takuya Iwamoto  
3rd Author's Affiliation Tokyo University of Agriculture and Technology (Tokyo Univ. of Agri. and Tech.)
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Speaker Author-1 
Date Time 2012-05-25 11:55:00 
Presentation Time 25 minutes 
Registration for LQE 
Paper # LQE2012-6 
Volume (vol) vol.112 
Number (no) no.62 
Page pp.25-28 
#Pages
Date of Issue 2012-05-18 (LQE) 


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