Paper Abstract and Keywords |
Presentation |
2013-11-22 10:00
Sleep-Wake Dependent Change in the Excitatory Cortical Networks Aritaka Nakamura, Akihiro Karashima (Tohoku Univ), Hiroshi Tsubokawa (Tohoku Fukushi Univ), Norihiro Katayama, Mitsuyuki Nakao (Tohoku Univ) MBE2013-66 |
Abstract |
(in Japanese) |
(See Japanese page) |
(in English) |
Recently, many sleep researchers are interested in the relationship between sleep-wake rhythm and synaptic plasticity. In this study, we performed whole-cell patch-clamp recordings from layer II/III pyramidal neurons of somatosensory cortex in acute slices of the rats that had been awake or asleep to investigate the effect of wake on excitatory synaptic transmission. We found that i) current-voltage relationship of EPSCs showed inward rectification, and ii) eEPSCs were depressed by Philanthotoxin 74, which is antagonist of $Ca^{2+}$-permeable AMPA receptors, in slices of waking animals. Both results show that $Ca^{2+}$-permeable AMPA receptors levels are high during wakefulness and periods of wakefulness are associated with an increase in cortical synaptic strength. |
Keyword |
(in Japanese) |
(See Japanese page) |
(in English) |
Sleep / Glutamate AMPA Receptor / Synaptic Homeostasis / / / / / |
Reference Info. |
IEICE Tech. Rep., vol. 113, no. 314, MBE2013-66, pp. 1-6, Nov. 2013. |
Paper # |
MBE2013-66 |
Date of Issue |
2013-11-15 (MBE) |
ISSN |
Print edition: ISSN 0913-5685 Online edition: ISSN 2432-6380 |
Copyright and reproduction |
All rights are reserved and no part of this publication may be reproduced or transmitted in any form or by any means, electronic or mechanical, including photocopy, recording, or any information storage and retrieval system, without permission in writing from the publisher. Notwithstanding, instructors are permitted to photocopy isolated articles for noncommercial classroom use without fee. (License No.: 10GA0019/12GB0052/13GB0056/17GB0034/18GB0034) |
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MBE2013-66 |
Conference Information |
Committee |
NC MBE |
Conference Date |
2013-11-22 - 2013-11-23 |
Place (in Japanese) |
(See Japanese page) |
Place (in English) |
Tohoku University |
Topics (in Japanese) |
(See Japanese page) |
Topics (in English) |
BCI/BMI, NC and MBE |
Paper Information |
Registration To |
MBE |
Conference Code |
2013-11-NC-MBE |
Language |
Japanese |
Title (in Japanese) |
(See Japanese page) |
Sub Title (in Japanese) |
(See Japanese page) |
Title (in English) |
Sleep-Wake Dependent Change in the Excitatory Cortical Networks |
Sub Title (in English) |
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Keyword(1) |
Sleep |
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Glutamate AMPA Receptor |
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Synaptic Homeostasis |
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1st Author's Name |
Aritaka Nakamura |
1st Author's Affiliation |
Tohoku University (Tohoku Univ) |
2nd Author's Name |
Akihiro Karashima |
2nd Author's Affiliation |
Tohoku University (Tohoku Univ) |
3rd Author's Name |
Hiroshi Tsubokawa |
3rd Author's Affiliation |
Tohoku Fukushi University (Tohoku Fukushi Univ) |
4th Author's Name |
Norihiro Katayama |
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Tohoku University (Tohoku Univ) |
5th Author's Name |
Mitsuyuki Nakao |
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Tohoku University (Tohoku Univ) |
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Speaker |
Author-1 |
Date Time |
2013-11-22 10:00:00 |
Presentation Time |
25 minutes |
Registration for |
MBE |
Paper # |
MBE2013-66 |
Volume (vol) |
vol.113 |
Number (no) |
no.314 |
Page |
pp.1-6 |
#Pages |
6 |
Date of Issue |
2013-11-15 (MBE) |
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