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Paper Abstract and Keywords
Presentation 2016-04-21 14:55
Fabrication of silicon chips with micro-apertures for formation of stable artificial bilayer lipid membranes
Daisuke Tadaki, Ayumi Hirano-Iwata (Tohoku Univ.), Kenichi Ishibashi (Hang-Ichi), Shun Araki, Miyu Yoshida, Kohei Arata, Takeshi Ohori, Hideaki Yamamoto, Michio Niwano (Tohoku Univ.) ED2016-2 Link to ES Tech. Rep. Archives: ED2016-2
Abstract (in Japanese) (See Japanese page) 
(in English) Bilayer lipid membranes (BLMs) that cover trillions of cells in our body have features of a nanometer scale thickness and a high resistivity. Artificially reconstituted BLMs serve, therefore, as a supporting material for incorporating ion channel proteins, and the incorporated BLMs can function as highly detective bio-sensors. Previously, we succeeded in the formation of mechanically stable BLMs by preparing membranes in micro-apertures formed in silicon (Si) chips using a semiconductor microfabrication technique. The BLM stabilization is due to the smoothly tapered shape of the aperture edge, which reduces the stress on the bilayer. However, there existed a fundamental problem that the micro-aperture oftentimes came with cracks and the reproducibility of fabricating proper chips was unsatisfactory. In order to solve the problem, we focused on the nanoscale structure at each step of Si chip fabrication, and succeeded in reaching 83% (n = 209) of the yield by improvements such as the change of etchant, the optimization of the temperature control of etchant, and the avoidance of the excessive etching.
Keyword (in Japanese) (See Japanese page) 
(in English) artificial bilayer lipid membranes (BLMs) / semiconductor microfabrication process / ion channel sensor / / / / /  
Reference Info. IEICE Tech. Rep., vol. 116, no. 14, ED2016-2, pp. 5-7, April 2016.
Paper # ED2016-2 
Date of Issue 2016-04-14 (ED) 
ISSN Print edition: ISSN 0913-5685    Online edition: ISSN 2432-6380
All rights are reserved and no part of this publication may be reproduced or transmitted in any form or by any means, electronic or mechanical, including photocopy, recording, or any information storage and retrieval system, without permission in writing from the publisher. Notwithstanding, instructors are permitted to photocopy isolated articles for noncommercial classroom use without fee. (License No.: 10GA0019/12GB0052/13GB0056/17GB0034/18GB0034)
Download PDF ED2016-2 Link to ES Tech. Rep. Archives: ED2016-2

Conference Information
Committee ED  
Conference Date 2016-04-21 - 2016-04-22 
Place (in Japanese) (See Japanese page) 
Place (in English)  
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Topics (in English)  
Paper Information
Registration To ED 
Conference Code 2016-04-ED 
Language Japanese 
Title (in Japanese) (See Japanese page) 
Sub Title (in Japanese) (See Japanese page) 
Title (in English) Fabrication of silicon chips with micro-apertures for formation of stable artificial bilayer lipid membranes 
Sub Title (in English)  
Keyword(1) artificial bilayer lipid membranes (BLMs)  
Keyword(2) semiconductor microfabrication process  
Keyword(3) ion channel sensor  
1st Author's Name Daisuke Tadaki  
1st Author's Affiliation Tohoku University (Tohoku Univ.)
2nd Author's Name Ayumi Hirano-Iwata  
2nd Author's Affiliation Tohoku University (Tohoku Univ.)
3rd Author's Name Kenichi Ishibashi  
3rd Author's Affiliation Hang-Ichi Corporation (Hang-Ichi)
4th Author's Name Shun Araki  
4th Author's Affiliation Tohoku University (Tohoku Univ.)
5th Author's Name Miyu Yoshida  
5th Author's Affiliation Tohoku University (Tohoku Univ.)
6th Author's Name Kohei Arata  
6th Author's Affiliation Tohoku University (Tohoku Univ.)
7th Author's Name Takeshi Ohori  
7th Author's Affiliation Tohoku University (Tohoku Univ.)
8th Author's Name Hideaki Yamamoto  
8th Author's Affiliation Tohoku University (Tohoku Univ.)
9th Author's Name Michio Niwano  
9th Author's Affiliation Tohoku University (Tohoku Univ.)
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Speaker Author-1 
Date Time 2016-04-21 14:55:00 
Presentation Time 25 minutes 
Registration for ED 
Paper # ED2016-2 
Volume (vol) vol.116 
Number (no) no.14 
Page pp.5-7 
Date of Issue 2016-04-14 (ED) 

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