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| Presentation | 2017-11-09 15:35 On the effect of noise on a mathematical model of the pancreatic beta cell Tomoyoshi Kojo, Hiroyasu Ando (Univ. of Tsukuba), Kantaro Fujiwara (Tokyo Univ. of Sci.), Masashi Yoshida, Masafumi Kakei (Jichi Med. Univ.)  CCS2017-25 |
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| Abstract | (in Japanese) | (See Japanese page) |
| (in English) | The membrane potential of pancreatic beta cells changes its value in accordance with insulin secretion. In normal beta cells, the change of membrane potential shows periodic bursting, while the bursting of cells in diabetes patients is not periodic, namely the insulin secretion is disordered. In this study, the dynamics of the membrane potential is reproduced by numerical simulation of a mathematical model, and the effect of noise on the model is investigated. As a result of the simulation, we confirm that the number of spikes which corresponds to insulin secretion increases due to noise. We also confirm that the stronger the noise amplitude is, the more the number of spikes increases. Furthermore, the number of spikes more increases for the parameters of the model in which the bursting is not periodic than for that of periodic bursting. This result implies that noise stimulation can promote the amount of insulin secretion for the disordered beta cell compared with the normal cell. Thus, the noisy stimulation would be useful for the remedy for diabetes. |
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| Keyword | (in Japanese) | (See Japanese page) |
| (in English) | Pancreatic beta cell, / Insulin secretion / Bursting / Noise / / / / | |
| Reference Info. | IEICE Tech. Rep., vol. 117, no. 288, CCS2017-25, pp. 25-28, Nov. 2017. | |
| Paper # | CCS2017-25 | |
| Date of Issue | 2017-11-02 (CCS) | |
| ISSN | Print edition: ISSN 0913-5685 Online edition: ISSN 2432-6380 | |
| Copyright and reproduction |
All rights are reserved and no part of this publication may be reproduced or transmitted in any form or by any means, electronic or mechanical, including photocopy, recording, or any information storage and retrieval system, without permission in writing from the publisher. Notwithstanding, instructors are permitted to photocopy isolated articles for noncommercial classroom use without fee. (License No.: 10GA0019/12GB0052/13GB0056/17GB0034/18GB0034) | |
| Download PDF | CCS2017-25 |
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| Conference Information | |
| Committee | CCS |
| Conference Date | 2017-11-09 - 2017-11-10 |
| Place (in Japanese) | (See Japanese page) |
| Place (in English) | Osaka Univ. |
| Topics (in Japanese) | (See Japanese page) |
| Topics (in English) | |
| Paper Information | |
| Registration To | CCS |
| Conference Code | 2017-11-CCS |
| Language | Japanese |
| Title (in Japanese) | (See Japanese page) |
| Sub Title (in Japanese) | (See Japanese page) |
| Title (in English) | On the effect of noise on a mathematical model of the pancreatic beta cell |
| Sub Title (in English) | |
| Keyword(1) | Pancreatic beta cell, |
| Keyword(2) | Insulin secretion |
| Keyword(3) | Bursting |
| Keyword(4) | Noise |
| Keyword(5) | |
| Keyword(6) | |
| Keyword(7) | |
| Keyword(8) | |
| 1st Author's Name | Tomoyoshi Kojo |
| 1st Author's Affiliation | University of Tsukuba (Univ. of Tsukuba) |
| 2nd Author's Name | Hiroyasu Ando |
| 2nd Author's Affiliation | University of Tsukuba (Univ. of Tsukuba) |
| 3rd Author's Name | Kantaro Fujiwara |
| 3rd Author's Affiliation | Tokyo University of Science (Tokyo Univ. of Sci.) |
| 4th Author's Name | Masashi Yoshida |
| 4th Author's Affiliation | Jichi Medical University Saitama Medical Center (Jichi Med. Univ.) |
| 5th Author's Name | Masafumi Kakei |
| 5th Author's Affiliation | Jichi Medical University Saitama Medical Center (Jichi Med. Univ.) |
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| Speaker | Author-1 |
| Date Time | 2017-11-09 15:35:00 |
| Presentation Time | 25 minutes |
| Registration for | CCS |
| Paper # | CCS2017-25 |
| Volume (vol) | vol.117 |
| Number (no) | no.288 |
| Page | pp.25-28 |
| #Pages | 4 |
| Date of Issue | 2017-11-02 (CCS) |
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