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Paper Abstract and Keywords
Presentation 2018-10-20 14:15
Behavioral testing and resting-state brain functional connectivity analysis of the methimazole-induced transient hypothyroidism mice
Yuto Yoshida, Ryusei Uchida, Katsuya Uchida, Keiichi Itoi, Mitsuyuki Nakao, Norihiro Katayama (Tohoku Univ.) MBE2018-33
Abstract (in Japanese) (See Japanese page) 
(in English) Decreased thyroid function in the fetal and juvenile period causes mental retardation and motor function decline. In this study, open-field behavioral testing and resting-state functional connectivity (rsFC) analysis of the brain were performed on transient hypothyroidism mice prepared by pharmacological manipulation. The rsFC analysis revealed that the negative correlation between the secondary motor cortex and the parietal temporal association area was stronger in the low activity mice of the test group than the control group. These results suggest that a histological abnormality of the brain is expressed as a difference in the structure of the rsFC network of the brain.
Keyword (in Japanese) (See Japanese page) 
(in English) resting-state functional connectivity / growth-retarded hypothyroid mouse / IOS imaging / open field test / / / /  
Reference Info. IEICE Tech. Rep., vol. 118, no. 257, MBE2018-33, pp. 31-36, Oct. 2018.
Paper # MBE2018-33 
Date of Issue 2018-10-13 (MBE) 
ISSN Online edition: ISSN 2432-6380
All rights are reserved and no part of this publication may be reproduced or transmitted in any form or by any means, electronic or mechanical, including photocopy, recording, or any information storage and retrieval system, without permission in writing from the publisher. Notwithstanding, instructors are permitted to photocopy isolated articles for noncommercial classroom use without fee. (License No.: 10GA0019/12GB0052/13GB0056/17GB0034/18GB0034)
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Conference Information
Committee NC MBE  
Conference Date 2018-10-19 - 2018-10-20 
Place (in Japanese) (See Japanese page) 
Place (in English) Tohoku Univ. 
Topics (in Japanese) (See Japanese page) 
Topics (in English)  
Paper Information
Registration To MBE 
Conference Code 2018-10-NC-MBE 
Language Japanese 
Title (in Japanese) (See Japanese page) 
Sub Title (in Japanese) (See Japanese page) 
Title (in English) Behavioral testing and resting-state brain functional connectivity analysis of the methimazole-induced transient hypothyroidism mice 
Sub Title (in English)  
Keyword(1) resting-state functional connectivity  
Keyword(2) growth-retarded hypothyroid mouse  
Keyword(3) IOS imaging  
Keyword(4) open field test  
1st Author's Name Yuto Yoshida  
1st Author's Affiliation Tohoku University (Tohoku Univ.)
2nd Author's Name Ryusei Uchida  
2nd Author's Affiliation Tohoku University (Tohoku Univ.)
3rd Author's Name Katsuya Uchida  
3rd Author's Affiliation Tohoku University (Tohoku Univ.)
4th Author's Name Keiichi Itoi  
4th Author's Affiliation Tohoku University (Tohoku Univ.)
5th Author's Name Mitsuyuki Nakao  
5th Author's Affiliation Tohoku University (Tohoku Univ.)
6th Author's Name Norihiro Katayama  
6th Author's Affiliation Tohoku University (Tohoku Univ.)
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Speaker Author-1 
Date Time 2018-10-20 14:15:00 
Presentation Time 25 minutes 
Registration for MBE 
Paper # MBE2018-33 
Volume (vol) vol.118 
Number (no) no.257 
Page pp.31-36 
Date of Issue 2018-10-13 (MBE) 

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