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| Presentation | 2019-04-18 15:45 Construction of an artificial cell membrane device and its application to a sensor for drug side effects Ayumi Hirano-Iwata, Daisuke Tadaki, Daichi Yamaura, Miki Kato, Maki Komiya (Tohoku Univ.), Haruka Inoue, Yuzuru Tozawa (Saitama Univ.), Teng Ma, Hideaki Yamamoto (Tohoku Univ.), Michio Niwano (Tohoku Fukushi Univ.)  ED2019-7 Link to ES Tech. Rep. Archives: ED2019-7 |
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| Abstract | (in Japanese) | (See Japanese page) |
| (in English) | Ion channel proteins are membrane proteins that regulate ion flows across cell membranes and have attracted attention not only as primary molecular targets for drug actions but also as major targets for drug-induced side effects. Reconstitution of ion channel proteins in artificial bilayer lipid membranes (BLMs) provides an excellent system for drug screenings. The advantage of this system is its versatility in terms of producing target channels, including those prepared by cell-free protein expression systems, in which pure proteins of various channel genotypes can be produced directly from a protein-encoding plasmid. However, the BLM system suffers from low experimental efficiency due to instability of the BLMs and difficulty in ion channel incorporation into BLMs. In this presentation, we will show you our recent approaches for addressing these issues based on nano- and micro-fabrication. Our approach leads to the realization of a BLM-based high-throughput platform for screening the effects of drugs that act on various ion channel genotypes. | |
| Keyword | (in Japanese) | (See Japanese page) |
| (in English) | ion channel / lipid bilayer / cell-free protein synthesis / silicon microfabrication / drug screening / / / | |
| Reference Info. | IEICE Tech. Rep., vol. 119, no. 9, ED2019-7, pp. 23-26, April 2019. | |
| Paper # | ED2019-7 | |
| Date of Issue | 2019-04-11 (ED) | |
| ISSN | Print edition: ISSN 0913-5685 Online edition: ISSN 2432-6380 | |
| Copyright and reproduction |
All rights are reserved and no part of this publication may be reproduced or transmitted in any form or by any means, electronic or mechanical, including photocopy, recording, or any information storage and retrieval system, without permission in writing from the publisher. Notwithstanding, instructors are permitted to photocopy isolated articles for noncommercial classroom use without fee. (License No.: 10GA0019/12GB0052/13GB0056/17GB0034/18GB0034) | |
| Download PDF | ED2019-7 Link to ES Tech. Rep. Archives: ED2019-7 |
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| Conference Information | |
| Committee | ED |
| Conference Date | 2019-04-18 - 2019-04-18 |
| Place (in Japanese) | (See Japanese page) |
| Place (in English) | RIEC, Tohoku Univ. |
| Topics (in Japanese) | (See Japanese page) |
| Topics (in English) | Organic devices, oxide devices, general |
| Paper Information | |
| Registration To | ED |
| Conference Code | 2019-04-ED |
| Language | Japanese |
| Title (in Japanese) | (See Japanese page) |
| Sub Title (in Japanese) | (See Japanese page) |
| Title (in English) | Construction of an artificial cell membrane device and its application to a sensor for drug side effects |
| Sub Title (in English) | |
| Keyword(1) | ion channel |
| Keyword(2) | lipid bilayer |
| Keyword(3) | cell-free protein synthesis |
| Keyword(4) | silicon microfabrication |
| Keyword(5) | drug screening |
| Keyword(6) | |
| Keyword(7) | |
| Keyword(8) | |
| 1st Author's Name | Ayumi Hirano-Iwata |
| 1st Author's Affiliation | Tohoku University (Tohoku Univ.) |
| 2nd Author's Name | Daisuke Tadaki |
| 2nd Author's Affiliation | Tohoku University (Tohoku Univ.) |
| 3rd Author's Name | Daichi Yamaura |
| 3rd Author's Affiliation | Tohoku University (Tohoku Univ.) |
| 4th Author's Name | Miki Kato |
| 4th Author's Affiliation | Tohoku University (Tohoku Univ.) |
| 5th Author's Name | Maki Komiya |
| 5th Author's Affiliation | Tohoku University (Tohoku Univ.) |
| 6th Author's Name | Haruka Inoue |
| 6th Author's Affiliation | Saitama University (Saitama Univ.) |
| 7th Author's Name | Yuzuru Tozawa |
| 7th Author's Affiliation | Saitama University (Saitama Univ.) |
| 8th Author's Name | Teng Ma |
| 8th Author's Affiliation | Tohoku University (Tohoku Univ.) |
| 9th Author's Name | Hideaki Yamamoto |
| 9th Author's Affiliation | Tohoku University (Tohoku Univ.) |
| 10th Author's Name | Michio Niwano |
| 10th Author's Affiliation | Tohoku Fukushi University (Tohoku Fukushi Univ.) |
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| Speaker | Author-1 |
| Date Time | 2019-04-18 15:45:00 |
| Presentation Time | 25 minutes |
| Registration for | ED |
| Paper # | ED2019-7 |
| Volume (vol) | vol.119 |
| Number (no) | no.9 |
| Page | pp.23-26 |
| #Pages | 4 |
| Date of Issue | 2019-04-11 (ED) |
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