Paper Abstract and Keywords |
Presentation |
2021-12-27 15:10
Drug development based on molecular self-assembly Yukio Nagasaki (U. Tsukuba) OME2021-38 Link to ES Tech. Rep. Archives: OME2021-38 |
Abstract |
(in Japanese) |
(See Japanese page) |
(in English) |
At the end of the 19th century, Paul Ehrlich found that methylene blue stains only the nerve endings of rabbits, so he thought, with a suitable choice of molecules, has no effect on healthy parts of the body and is influenced to the disease sites. He called it a "magic bullet" for such drugs. In the 21st century, a molecular-targeted drug was put into practical use, and his idea was realized. By the molecular target drugs, have cancer patients disappeared from the world? The answer is no, in reality, the number of deaths from cancer patients is steadily increasing year by year. In addition to developing further effective molecular-targeted drugs, a new concept of "medicine" is indispensable for reducing patient pain and improving efficacy. The objective of this research is to construct a new modality for the development of novel drugs by a new concept of molecular-assembling medicines following synthetic organic molecules and biomolecular drugs such as antibody drugs and nucleic acid drugs. This concept is based on the observation that self-assembling antioxidants suppressed their adverse effects significantly and accumulate in the inflammation site and effectively eliminate reactive oxygen species (ROS). Our results indicate the possibility that biological functions and therapeutic effects that cannot be obtained with low molecular weight compounds alone can be controlled by organizing small molecules. In recent years, in the field of drug discovery and development, several medicines whose medicinal effects are exerted only by self-assembling have been discovered. By developing our proposed research, we would like to achieve a system that is friendly to patients as a basis for the creation of an innovative drug discovery industry. |
Keyword |
(in Japanese) |
(See Japanese page) |
(in English) |
Molecular self-assembling drugs / Antioxidants / Amino acid / Short chain fatty acids / Reactive oxygen species / / / |
Reference Info. |
IEICE Tech. Rep., vol. 121, no. 315, OME2021-38, pp. 9-14, Dec. 2021. |
Paper # |
OME2021-38 |
Date of Issue |
2021-12-20 (OME) |
ISSN |
Online edition: ISSN 2432-6380 |
Copyright and reproduction |
All rights are reserved and no part of this publication may be reproduced or transmitted in any form or by any means, electronic or mechanical, including photocopy, recording, or any information storage and retrieval system, without permission in writing from the publisher. Notwithstanding, instructors are permitted to photocopy isolated articles for noncommercial classroom use without fee. (License No.: 10GA0019/12GB0052/13GB0056/17GB0034/18GB0034) |
Download PDF |
OME2021-38 Link to ES Tech. Rep. Archives: OME2021-38 |
Conference Information |
Committee |
OME |
Conference Date |
2021-12-27 - 2021-12-28 |
Place (in Japanese) |
(See Japanese page) |
Place (in English) |
Okinawaken Seinen Kaikan |
Topics (in Japanese) |
(See Japanese page) |
Topics (in English) |
bio-technology, surface and interfacial phenomena, measurement and observation, electronics, and other researches relating these |
Paper Information |
Registration To |
OME |
Conference Code |
2021-12-OME |
Language |
Japanese |
Title (in Japanese) |
(See Japanese page) |
Sub Title (in Japanese) |
(See Japanese page) |
Title (in English) |
Drug development based on molecular self-assembly |
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Keyword(1) |
Molecular self-assembling drugs |
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Antioxidants |
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Amino acid |
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Short chain fatty acids |
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Reactive oxygen species |
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1st Author's Name |
Yukio Nagasaki |
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University of Tsukuba (U. Tsukuba) |
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Speaker |
Author-1 |
Date Time |
2021-12-27 15:10:00 |
Presentation Time |
35 minutes |
Registration for |
OME |
Paper # |
OME2021-38 |
Volume (vol) |
vol.121 |
Number (no) |
no.315 |
Page |
pp.9-14 |
#Pages |
6 |
Date of Issue |
2021-12-20 (OME) |
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