IEICE Technical Committee Submission System
Conference Paper's Information
Online Proceedings
[Sign in]
Tech. Rep. Archives
 Go Top Page Go Previous   [Japanese] / [English] 

Paper Abstract and Keywords
Presentation 2021-12-27 15:10
Drug development based on molecular self-assembly
Yukio Nagasaki (U. Tsukuba) OME2021-38 Link to ES Tech. Rep. Archives: OME2021-38
Abstract (in Japanese) (See Japanese page) 
(in English) At the end of the 19th century, Paul Ehrlich found that methylene blue stains only the nerve endings of rabbits, so he thought, with a suitable choice of molecules, has no effect on healthy parts of the body and is influenced to the disease sites. He called it a "magic bullet" for such drugs. In the 21st century, a molecular-targeted drug was put into practical use, and his idea was realized. By the molecular target drugs, have cancer patients disappeared from the world? The answer is no, in reality, the number of deaths from cancer patients is steadily increasing year by year. In addition to developing further effective molecular-targeted drugs, a new concept of "medicine" is indispensable for reducing patient pain and improving efficacy. The objective of this research is to construct a new modality for the development of novel drugs by a new concept of molecular-assembling medicines following synthetic organic molecules and biomolecular drugs such as antibody drugs and nucleic acid drugs. This concept is based on the observation that self-assembling antioxidants suppressed their adverse effects significantly and accumulate in the inflammation site and effectively eliminate reactive oxygen species (ROS). Our results indicate the possibility that biological functions and therapeutic effects that cannot be obtained with low molecular weight compounds alone can be controlled by organizing small molecules. In recent years, in the field of drug discovery and development, several medicines whose medicinal effects are exerted only by self-assembling have been discovered. By developing our proposed research, we would like to achieve a system that is friendly to patients as a basis for the creation of an innovative drug discovery industry.
Keyword (in Japanese) (See Japanese page) 
(in English) Molecular self-assembling drugs / Antioxidants / Amino acid / Short chain fatty acids / Reactive oxygen species / / /  
Reference Info. IEICE Tech. Rep., vol. 121, no. 315, OME2021-38, pp. 9-14, Dec. 2021.
Paper # OME2021-38 
Date of Issue 2021-12-20 (OME) 
ISSN Online edition: ISSN 2432-6380
Copyright
and
reproduction
All rights are reserved and no part of this publication may be reproduced or transmitted in any form or by any means, electronic or mechanical, including photocopy, recording, or any information storage and retrieval system, without permission in writing from the publisher. Notwithstanding, instructors are permitted to photocopy isolated articles for noncommercial classroom use without fee. (License No.: 10GA0019/12GB0052/13GB0056/17GB0034/18GB0034)
Download PDF OME2021-38 Link to ES Tech. Rep. Archives: OME2021-38

Conference Information
Committee OME  
Conference Date 2021-12-27 - 2021-12-28 
Place (in Japanese) (See Japanese page) 
Place (in English) Okinawaken Seinen Kaikan 
Topics (in Japanese) (See Japanese page) 
Topics (in English) bio-technology, surface and interfacial phenomena, measurement and observation, electronics, and other researches relating these 
Paper Information
Registration To OME 
Conference Code 2021-12-OME 
Language Japanese 
Title (in Japanese) (See Japanese page) 
Sub Title (in Japanese) (See Japanese page) 
Title (in English) Drug development based on molecular self-assembly 
Sub Title (in English)  
Keyword(1) Molecular self-assembling drugs  
Keyword(2) Antioxidants  
Keyword(3) Amino acid  
Keyword(4) Short chain fatty acids  
Keyword(5) Reactive oxygen species  
Keyword(6)  
Keyword(7)  
Keyword(8)  
1st Author's Name Yukio Nagasaki  
1st Author's Affiliation University of Tsukuba (U. Tsukuba)
2nd Author's Name  
2nd Author's Affiliation ()
3rd Author's Name  
3rd Author's Affiliation ()
4th Author's Name  
4th Author's Affiliation ()
5th Author's Name  
5th Author's Affiliation ()
6th Author's Name  
6th Author's Affiliation ()
7th Author's Name  
7th Author's Affiliation ()
8th Author's Name  
8th Author's Affiliation ()
9th Author's Name  
9th Author's Affiliation ()
10th Author's Name  
10th Author's Affiliation ()
11th Author's Name  
11th Author's Affiliation ()
12th Author's Name  
12th Author's Affiliation ()
13th Author's Name  
13th Author's Affiliation ()
14th Author's Name  
14th Author's Affiliation ()
15th Author's Name  
15th Author's Affiliation ()
16th Author's Name  
16th Author's Affiliation ()
17th Author's Name  
17th Author's Affiliation ()
18th Author's Name  
18th Author's Affiliation ()
19th Author's Name  
19th Author's Affiliation ()
20th Author's Name  
20th Author's Affiliation ()
Speaker Author-1 
Date Time 2021-12-27 15:10:00 
Presentation Time 35 minutes 
Registration for OME 
Paper # OME2021-38 
Volume (vol) vol.121 
Number (no) no.315 
Page pp.9-14 
#Pages
Date of Issue 2021-12-20 (OME) 


[Return to Top Page]

[Return to IEICE Web Page]


The Institute of Electronics, Information and Communication Engineers (IEICE), Japan