Paper Abstract and Keywords |
Presentation |
2007-08-10 11:30
Protective mechanism of the inner ear from traumatic noise exposure actuated by heat stress Michio Murakoshi, Naohiro Yoshida, Yoko Kitsunai, Koji Iida, Shun Kumano, Takashi Suzuki, Toshimitsu Kobayashi, Hiroshi Wada (Tohoku Univ.) EA2007-49 |
Abstract |
(in Japanese) |
(See Japanese page) |
(in English) |
Noise-induced hearing loss was reported to be decreased by raising the body temperature before traumatic noise exposure, i.e., heat stress. However, the protective mechanism of the inner ear against such traumatic exposure remains unknown. In the present study, the mechanical properties and the amount of filamentous actin of outer hair cells (OHCs) in mice with or without heat stress were measured by atomic force microscopy and confocal laser scanning microscopy, respectively. The conditioning by heat stress caused an increase in F-actin of the OHCs, leading to an increase in their Young’s modulus. These results suggest that OHCs exposed to prior heat stress possibly experience less strain when they are exposed to loud noise, resulting in protection from traumatic noise exposure. |
Keyword |
(in Japanese) |
(See Japanese page) |
(in English) |
Heat Stress / Outer Hair Cell / Young's Modulus / Filamentous Actin / Prestin / Heat Shock Protein / Distortion Product Otoacoustic Emission / Atomic Force Microscopy |
Reference Info. |
IEICE Tech. Rep., vol. 107, no. 187, EA2007-49, pp. 19-24, Aug. 2007. |
Paper # |
EA2007-49 |
Date of Issue |
2007-08-03 (EA) |
ISSN |
Print edition: ISSN 0913-5685 Online edition: ISSN 2432-6380 |
Copyright and reproduction |
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EA2007-49 |
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