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Paper Abstract and Keywords
Presentation 2008-03-13 13:30
k shortest path analysis of hippocampal signal transduction change by Alzheimer's gene regulations.
Ryoji Yanashima, Yoshiya Matsubara, Noriyuki Kitagawa, Shinichi Kikuchi, Koutaro Oka, Masaru Tomita (Keio Univ) NC2007-154
Abstract (in Japanese) (See Japanese page) 
(in English) Alzheimer's disease (AD) has been studied for the changes of molecules such as amyloid β. Few studies have investigated the change of the whole signal transduction system, preventing the elucidation of the mechanism. We aimed to elucidate the structural features of human hippocampal signal transduction system and the rules and mechanisms which emerge in AD. We constructed AD specific signal transduction network as a graph using gene expression and weighted directed signal transduction pathway data of hippocampus, and evaluated the changes of the system by commonly used statistical indexes and k shortest path. As a result, although the network density, transitivity, average clustering coefficient and shortest path length in the AD network resembled those in the network, the nodes of which were removed randomly, the robustness differed in the specific input and output sets in the k shortest path analysis. Applying this model, we successfully identified the changes of robustness in human hippocampal signal transductions in AD due to the differential gene expressions.
Keyword (in Japanese) (See Japanese page) 
(in English) Signal transduction / k shortest path / Gene regulations / Alzheimer's disease / / / /  
Reference Info. IEICE Tech. Rep., vol. 107, no. 542, NC2007-154, pp. 249-254, March 2008.
Paper # NC2007-154 
Date of Issue 2008-03-05 (NC) 
ISSN Print edition: ISSN 0913-5685    Online edition: ISSN 2432-6380
Copyright
and
reproduction		 All rights are reserved and no part of this publication may be reproduced or transmitted in any form or by any means, electronic or mechanical, including photocopy, recording, or any information storage and retrieval system, without permission in writing from the publisher. Notwithstanding, instructors are permitted to photocopy isolated articles for noncommercial classroom use without fee. (License No.: 10GA0019/12GB0052/13GB0056/17GB0034/18GB0034)
Download PDF NC2007-154

Conference Information
Committee NC MBE  
Conference Date 2008-03-12 - 2008-03-14 
Place (in Japanese) (See Japanese page) 
Place (in English) Tamagawa Univ 
Topics (in Japanese) (See Japanese page) 
Topics (in English)  
Paper Information
Registration To NC 
Conference Code 2008-03-NC-MBE 
Language Japanese 
Title (in Japanese) (See Japanese page) 
Sub Title (in Japanese) (See Japanese page) 
Title (in English) k shortest path analysis of hippocampal signal transduction change by Alzheimer's gene regulations. 
Sub Title (in English)  
Keyword(1) Signal transduction  
Keyword(2) k shortest path  
Keyword(3) Gene regulations  
Keyword(4) Alzheimer's disease  
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1st Author's Name Ryoji Yanashima  
1st Author's Affiliation Keio University (Keio Univ)
2nd Author's Name Yoshiya Matsubara  
2nd Author's Affiliation Keio University (Keio Univ)
3rd Author's Name Noriyuki Kitagawa  
3rd Author's Affiliation Keio University (Keio Univ)
4th Author's Name Shinichi Kikuchi  
4th Author's Affiliation Keio University (Keio Univ)
5th Author's Name Koutaro Oka  
5th Author's Affiliation Keio University (Keio Univ)
6th Author's Name Masaru Tomita  
6th Author's Affiliation Keio University (Keio Univ)
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Speaker Author-1 
Date Time 2008-03-13 13:30:00 
Presentation Time 20 minutes 
Registration for NC 
Paper # NC2007-154 
Volume (vol) vol.107 
Number (no) no.542 
Page pp.249-254 
#Pages 6 
Date of Issue 2008-03-05 (NC) 

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