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| 講演名 | 2009-01-19 11:45 MR Spectroscopy of Skeletal Muscle in Male Patients with Obstructive Sleep Apnea ○Chih-Wei Yu・Tiffany Ting-Fang Shih・Meng-Yueh Chien（National Taiwan Univ.）・Peilin Lee（National Taiwan Hospital）・Chao-Yu Hsu・Bang-Bin Chen（National Taiwan Univ.）・Yi-Miau Chen（National Taiwan Hospital）  MI2008-61 |
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| 抄録 | （和） | PURPOSE To investigate extra- (EMCL) and intramyocellular (IMCL) lipid changes in skeletal muscle by means of proton magnetic resonance spectroscopy (1H-MRS) in male patients with obstructive sleep apnea (OSA). MATERIAL AND METHODS Eighteen male patients with documented OSA and eighteen age- and BMI-matched male volunteers (age ranged 50.7 +/- 5.7 vs. 50.4 +/- 6.9 years; BMI ranged 25.9 +/- 2.9 vs. 25.7 +/- 2.7, respectively) were consecutively accrued in this study. 1H-MRS of the right adductor magnus muscle was performed on a 1.5T clinical MR scanner. EMCL fraction was defined as the ratio of the integration of EMCL methylene (-CH2) and EMCL methyl (-CH3) to creatine resonances. IMCL fraction was defined as the ratio of the integration of IMCL (-CH2) and IMCL (-CH3) to creatine resonances. The strength, expressed by maximum voluntary contractions (MVC), and endurance of the thigh muscles were measured by using an isokinetic dynamometer (Cybex 6000). Variables of both groups were compared using paired sample t test. RESULTS OSA patients had significantly lower value of IMCL fraction (10.3 vs. 14.1, P = 0.03) and EMCL fraction (14.1 vs. 24.7, P = 0.01) when compared with normal volunteers. OSA patients had significantly lower value of muscle strength (134.0 vs. 158.7, P < 0.001) and endurance (43.6% vs. 61.6%, P < 0.001) when compared with normal volunteers. No significant correlation between the IMCL or EMCL fraction and the muscle strength or endurance. CONCLUSION 1H-MRS demonstrated both decreased IMCL and EMCL content in male patients with OSA. No significant correlation between muscle lipid measurement and its function. |
| （英） | PURPOSE To investigate extra- (EMCL) and intramyocellular (IMCL) lipid changes in skeletal muscle by means of proton magnetic resonance spectroscopy (1H-MRS) in male patients with obstructive sleep apnea (OSA). MATERIAL AND METHODS Eighteen male patients with documented OSA and eighteen age- and BMI-matched male volunteers (age ranged 50.7 +/- 5.7 vs. 50.4 +/- 6.9 years; BMI ranged 25.9 +/- 2.9 vs. 25.7 +/- 2.7, respectively) were consecutively accrued in this study. 1H-MRS of the right adductor magnus muscle was performed on a 1.5T clinical MR scanner. EMCL fraction was defined as the ratio of the integration of EMCL methylene (-CH2) and EMCL methyl (-CH3) to creatine resonances. IMCL fraction was defined as the ratio of the integration of IMCL (-CH2) and IMCL (-CH3) to creatine resonances. The strength, expressed by maximum voluntary contractions (MVC), and endurance of the thigh muscles were measured by using an isokinetic dynamometer (Cybex 6000). Variables of both groups were compared using paired sample t test. RESULTS OSA patients had significantly lower value of IMCL fraction (10.3 vs. 14.1, P = 0.03) and EMCL fraction (14.1 vs. 24.7, P = 0.01) when compared with normal volunteers. OSA patients had significantly lower value of muscle strength (134.0 vs. 158.7, P < 0.001) and endurance (43.6% vs. 61.6%, P < 0.001) when compared with normal volunteers. No significant correlation between the IMCL or EMCL fraction and the muscle strength or endurance. CONCLUSION 1H-MRS demonstrated both decreased IMCL and EMCL content in male patients with OSA. No significant correlation between muscle lipid measurement and its function. |
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| キーワード | （和） | proton magnetic resonance spectroscopy (1H-MRS) / obstructive sleep apnea (OSA) / skeletal muscle / lipid / / / / |
| （英） | proton magnetic resonance spectroscopy (1H-MRS) / obstructive sleep apnea (OSA) / skeletal muscle / lipid / / / / | |
| 文献情報 | 信学技報, vol. 108, no. 385, MI2008-61, pp. 21-24, 2009年1月. | |
| 資料番号 | MI2008-61 | |
| 発行日 | 2009-01-12 (MI) | |
| ISSN | Print edition: ISSN 0913-5685 Online edition: ISSN 2432-6380 | |
| 著作権に ついて |
技術研究報告に掲載された論文の著作権は電子情報通信学会に帰属します．(許諾番号：10GA0019/12GB0052/13GB0056/17GB0034/18GB0034) | |
| PDFダウンロード | MI2008-61 |
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