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Paper Abstract and Keywords
Presentation 2009-03-12 13:00
Reproduction of transmural dispersion of repolarization based on cleft potential hypothesis
Shingo Suzuki (Osaka Univ/Nat'l Cardiovasc. Center), Takashi Ashihara (Shiga Univ. Med. Sci.), Ryo Haraguchi (Nat'l Cardiovasc. Center), Kunichika Tsumoto, Shingo Murakami, Yoshihisa Kurachi (Osaka Univ.), Kazuo Nakazawa (Nat'l Cardiovasc. Center) MBE2008-110
Abstract (in Japanese) (See Japanese page) 
(in English) Gap junctions in cardiac myocytes are required to the excitation propagation in a heart. However, the existence of the gap junctions is insufficient to reproduce the transmural dispersion of repolarization which forms T wave of the electrocardiogram. In this study, we focus on a hypothesis of propagation mechanism "cleft potential mechanism" (so-called electric field mechanism) where the narrow cleft space between the cardiac myocytes brings the electrical coupling. Our results show that this mechanism can simultaneously reproduce both the large conduction velocity and the large transmural dispersion of repolarization.
Keyword (in Japanese) (See Japanese page) 
(in English) cleft potential / excitation propagation / transmural dispersion / gap junction / simulation / / /  
Reference Info. IEICE Tech. Rep., vol. 108, no. 479, MBE2008-110, pp. 83-88, March 2009.
Paper # MBE2008-110 
Date of Issue 2009-03-04 (MBE) 
ISSN Print edition: ISSN 0913-5685    Online edition: ISSN 2432-6380
Copyright
and
reproduction		 All rights are reserved and no part of this publication may be reproduced or transmitted in any form or by any means, electronic or mechanical, including photocopy, recording, or any information storage and retrieval system, without permission in writing from the publisher. Notwithstanding, instructors are permitted to photocopy isolated articles for noncommercial classroom use without fee. (License No.: 10GA0019/12GB0052/13GB0056/17GB0034/18GB0034)
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Conference Information
Committee NC MBE  
Conference Date 2009-03-11 - 2009-03-13 
Place (in Japanese) (See Japanese page) 
Place (in English) Tamagawa Univ. 
Topics (in Japanese) (See Japanese page) 
Topics (in English)  
Paper Information
Registration To MBE 
Conference Code 2009-03-NC-MBE 
Language Japanese 
Title (in Japanese) (See Japanese page) 
Sub Title (in Japanese) (See Japanese page) 
Title (in English) Reproduction of transmural dispersion of repolarization based on cleft potential hypothesis 
Sub Title (in English)  
Keyword(1) cleft potential  
Keyword(2) excitation propagation  
Keyword(3) transmural dispersion  
Keyword(4) gap junction  
Keyword(5) simulation  
Keyword(6)  
Keyword(7)  
Keyword(8)  
1st Author's Name Shingo Suzuki  
1st Author's Affiliation Osaka University/National Cardiovascular Center (Osaka Univ/Nat'l Cardiovasc. Center)
2nd Author's Name Takashi Ashihara  
2nd Author's Affiliation Shiga University of Medical Science (Shiga Univ. Med. Sci.)
3rd Author's Name Ryo Haraguchi  
3rd Author's Affiliation National Cardiovascular Center (Nat'l Cardiovasc. Center)
4th Author's Name Kunichika Tsumoto  
4th Author's Affiliation Osaka University (Osaka Univ.)
5th Author's Name Shingo Murakami  
5th Author's Affiliation Osaka University (Osaka Univ.)
6th Author's Name Yoshihisa Kurachi  
6th Author's Affiliation Osaka University (Osaka Univ.)
7th Author's Name Kazuo Nakazawa  
7th Author's Affiliation National Cardiovascular Center (Nat'l Cardiovasc. Center)
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Speaker Author-1 
Date Time 2009-03-12 13:00:00 
Presentation Time 25 minutes 
Registration for MBE 
Paper # MBE2008-110 
Volume (vol) vol.108 
Number (no) no.479 
Page pp.83-88 
#Pages 6 
Date of Issue 2009-03-04 (MBE) 

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