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Paper Abstract and Keywords
Presentation 2009-08-06 14:20
Parameter estimation by combination of differential elimination and genetic algorithm in the biological network including unmeasured variables
Masahiko Nakatsui, Katsuhisa Horimoto (AIST) CST2009-13
Abstract (in Japanese) (See Japanese page) 
(in English) In this study, a symbolic-numeric method is proposed to estimate kinetic parameters on the entire network, only from time-series data of a few variables. First, we utilize the differential elimination, which is one of the algebraic approaches for rewriting system of differential equations into another equivalent system, to derive constraints between kinetic parameters. Second, we estimate kinetic parameters by the introduction of these constraints into objective functions in a genetic algorithm (GA).
By a simulation study for artificial network including 1 measured and 3 unmeasured variables, our symbolic-numeric method estimated precisely kinetic parameters in the simulated network, while GA failed.
Keyword (in Japanese) (See Japanese page) 
(in English) Symbolic Computing / Differential Elimination / Numerical Parameter Optimization / Real-coded Genetic Algorithms / / / /  
Reference Info. IEICE Tech. Rep., vol. 109, Aug. 2009.
Paper #  
Date of Issue 2009-07-30 (CST) 
ISSN Print edition: ISSN 0913-5685    Online edition: ISSN 2432-6380
Copyright
and
reproduction		 All rights are reserved and no part of this publication may be reproduced or transmitted in any form or by any means, electronic or mechanical, including photocopy, recording, or any information storage and retrieval system, without permission in writing from the publisher. Notwithstanding, instructors are permitted to photocopy isolated articles for noncommercial classroom use without fee. (License No.: 10GA0019/12GB0052/13GB0056/17GB0034/18GB0034)
Download PDF CST2009-13

Conference Information
Committee MSS  
Conference Date 2009-08-06 - 2009-08-07 
Place (in Japanese) (See Japanese page) 
Place (in English) JAIST Tokyo Campus 
Topics (in Japanese) (See Japanese page) 
Topics (in English) Systems Biology, etc 
Paper Information
Registration To MSS 
Conference Code 2009-08-CST 
Language Japanese 
Title (in Japanese) (See Japanese page) 
Sub Title (in Japanese) (See Japanese page) 
Title (in English) Parameter estimation by combination of differential elimination and genetic algorithm in the biological network including unmeasured variables 
Sub Title (in English)  
Keyword(1) Symbolic Computing  
Keyword(2) Differential Elimination  
Keyword(3) Numerical Parameter Optimization  
Keyword(4) Real-coded Genetic Algorithms  
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1st Author's Name Masahiko Nakatsui  
1st Author's Affiliation National Institute of Industrial Science and Technology (AIST)
2nd Author's Name Katsuhisa Horimoto  
2nd Author's Affiliation National Institute of Industrial Science and Technology (AIST)
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Speaker Author-1 
Date Time 2009-08-06 14:20:00 
Presentation Time 50 minutes 
Registration for MSS 
Paper # CST2009-13 
Volume (vol) vol.109 
Number (no) no.165 
Page pp.7-12 
#Pages 6 
Date of Issue 2009-07-30 (CST) 

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