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Paper Abstract and Keywords
Presentation 2010-01-28 11:40
Estimation algorithm using direct search method in PET neuroreceptor quantification
Yosuke Okanishi (Chiba Univ.), Yuichi Kimura, Mikio Suga (National Inst. of Radiological Sci./Chiba Univ.) MI2009-84
Abstract (in Japanese) (See Japanese page) 
(in English) In a compartment model analysis using positron emission tomography (PET), some problems arises in non-linear estimation: misconvergence, dependence in estimation results on a initial values and calculation time. This study aimed at investigating a direct search method. In the algorithm, feature space on a time history of radioactivity concentration in tissues was composed using a measured time history in arterial plasma and a set of rate constraints in the model that covered physiologically expected range. The space was fluctuated by the noise observed in ROI-based PET study. The dynamic PET data were projected onto the feature space, and then clustered using the Mahalanobis distance. The method was validated with simulation based on ROI studies for [11C]TMSX. Especially, the kinetic parameter K1 and a total distribution volume, VT , were estimated well. If VT was fixed at this estimate and the algorithem was applied again, a performance in model estimation on a neuroreceptor density was approximately 20% of quartile deviation that was 40% without the constraint.
Keyword (in Japanese) (See Japanese page) 
(in English) kinetic analysis / compartment model / molecular imaging / nuclear medicinal / PET / / /  
Reference Info. IEICE Tech. Rep., vol. 109, no. 407, MI2009-84, pp. 53-56, Jan. 2010.
Paper # MI2009-84 
Date of Issue 2010-01-21 (MI) 
ISSN Print edition: ISSN 0913-5685    Online edition: ISSN 2432-6380
Copyright
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reproduction		 All rights are reserved and no part of this publication may be reproduced or transmitted in any form or by any means, electronic or mechanical, including photocopy, recording, or any information storage and retrieval system, without permission in writing from the publisher. Notwithstanding, instructors are permitted to photocopy isolated articles for noncommercial classroom use without fee. (License No.: 10GA0019/12GB0052/13GB0056/17GB0034/18GB0034)
Download PDF MI2009-84

Conference Information
Committee MI  
Conference Date 2010-01-28 - 2010-01-29 
Place (in Japanese) (See Japanese page) 
Place (in English) Naha-Bunka-Tenbusu 
Topics (in Japanese) (See Japanese page) 
Topics (in English) Medical Imaging 
Paper Information
Registration To MI 
Conference Code 2010-01-MI 
Language Japanese 
Title (in Japanese) (See Japanese page) 
Sub Title (in Japanese) (See Japanese page) 
Title (in English) Estimation algorithm using direct search method in PET neuroreceptor quantification 
Sub Title (in English)  
Keyword(1) kinetic analysis  
Keyword(2) compartment model  
Keyword(3) molecular imaging  
Keyword(4) nuclear medicinal  
Keyword(5) PET  
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1st Author's Name Yosuke Okanishi  
1st Author's Affiliation Chiba University (Chiba Univ.)
2nd Author's Name Yuichi Kimura  
2nd Author's Affiliation National Institute of Radiological Sciences/Chiba University (National Inst. of Radiological Sci./Chiba Univ.)
3rd Author's Name Mikio Suga  
3rd Author's Affiliation National Institute of Radiological Sciences/Chiba University (National Inst. of Radiological Sci./Chiba Univ.)
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Speaker Author-1 
Date Time 2010-01-28 11:40:00 
Presentation Time 30 minutes 
Registration for MI 
Paper # MI2009-84 
Volume (vol) vol.109 
Number (no) no.407 
Page pp.53-56 
#Pages 4 
Date of Issue 2010-01-21 (MI) 

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