Information: Join today and make your research activities more affordable! Technical workshop participation fees and annual registration fees are available at member rates.
Notice: [Important] Announcement of Changes to Registration Fee Payment and Manuscript Upload Procedures for IEICE Technical Meetings
IEICE Technical Committee Submission System
Conference Paper's Information		 Online Proceedings
[Sign in]
Tech. Rep. Archives
 Go Top Page Go Previous   [Japanese] / [English] 

Paper Abstract and Keywords
Presentation 2010-01-28 10:05
A Strategy to Improve PET Neuroreceptor Analysis MA1 Based on Statistics of Measurement Errors
Naoki Hoshino, Hidekata Hontani (Nagoya Inst. of Tech.), Mika Naganawa, Kazuya Sakaguchi (National Inst. of Radiological Sci.), Muneyuki Sakata, Kiichi Ishiwata (Tokyo Metro Inst. of Gerontology), Yuichi Kimura (National Inst. of Radiological Sci.) MI2009-76
Abstract (in Japanese) (See Japanese page) 
(in English) In this article, we propose a new method for improving MA1, which
estimates total distribution volume $V_{\rm T}$, the parameter
reflecting a neuroreceptor density. MA1 applies a linear regression
analysis to a set of data computed from the tissue time activity curve
(tTAC) and the plasma time activity curve (pTAC) to obtain the value
of $V_{\rm T}$. The problem is that the linear regression is not
supported by the statistics of the noise included in the data. Hence,
the proposed method de-noises measured tTAC to estimate the
corresponding true tTAC by means of MAP estimation. For the MAP
estimation, we need the prior distribution of tTAC and the likelihood
one on the measured tTAC. The proposed method estimates the former one
based on simulations and estimates the latter one from the
measurements. We evaluated the performance of MA1 and of the proposed
method by using simulated tTACs and by using clinical data considering
$^{11}$C-SA4503 that is a probe of $\sigma_{1}$ receptors. The
evaluation results show that our proposed method improves the
variances of the estimates.
Keyword (in Japanese) (See Japanese page) 
(in English) PET / total distribution volume / MA1 / MAP estimation / denoising / kinetic analysis / /  
Reference Info. IEICE Tech. Rep., vol. 109, no. 407, MI2009-76, pp. 7-12, Jan. 2010.
Paper # MI2009-76 
Date of Issue 2010-01-21 (MI) 
ISSN Print edition: ISSN 0913-5685    Online edition: ISSN 2432-6380
Copyright
and
reproduction		 All rights are reserved and no part of this publication may be reproduced or transmitted in any form or by any means, electronic or mechanical, including photocopy, recording, or any information storage and retrieval system, without permission in writing from the publisher. Notwithstanding, instructors are permitted to photocopy isolated articles for noncommercial classroom use without fee. (License No.: 10GA0019/12GB0052/13GB0056/17GB0034/18GB0034)
Download PDF MI2009-76

Conference Information
Committee MI  
Conference Date 2010-01-28 - 2010-01-29 
Place (in Japanese) (See Japanese page) 
Place (in English) Naha-Bunka-Tenbusu 
Topics (in Japanese) (See Japanese page) 
Topics (in English) Medical Imaging 
Paper Information
Registration To MI 
Conference Code 2010-01-MI 
Language Japanese 
Title (in Japanese) (See Japanese page) 
Sub Title (in Japanese) (See Japanese page) 
Title (in English) A Strategy to Improve PET Neuroreceptor Analysis MA1 Based on Statistics of Measurement Errors 
Sub Title (in English)  
Keyword(1) PET  
Keyword(2) total distribution volume  
Keyword(3) MA1  
Keyword(4) MAP estimation  
Keyword(5) denoising  
Keyword(6) kinetic analysis  
Keyword(7)  
Keyword(8)  
1st Author's Name Naoki Hoshino  
1st Author's Affiliation Nagoya Institute of Technology (Nagoya Inst. of Tech.)
2nd Author's Name Hidekata Hontani  
2nd Author's Affiliation Nagoya Institute of Technology (Nagoya Inst. of Tech.)
3rd Author's Name Mika Naganawa  
3rd Author's Affiliation Molecular Imaging Center, National Institute of Radiological Sciences (National Inst. of Radiological Sci.)
4th Author's Name Kazuya Sakaguchi  
4th Author's Affiliation Molecular Imaging Center, National Institute of Radiological Sciences (National Inst. of Radiological Sci.)
5th Author's Name Muneyuki Sakata  
5th Author's Affiliation Positron Medical Center, Tokyo Metropolitan Institute of Gerontology (Tokyo Metro Inst. of Gerontology)
6th Author's Name Kiichi Ishiwata  
6th Author's Affiliation Positron Medical Center, Tokyo Metropolitan Institute of Gerontology (Tokyo Metro Inst. of Gerontology)
7th Author's Name Yuichi Kimura  
7th Author's Affiliation Molecular Imaging Center, National Institute of Radiological Sciences (National Inst. of Radiological Sci.)
8th Author's Name  
8th Author's Affiliation ()
9th Author's Name  
9th Author's Affiliation ()
10th Author's Name  
10th Author's Affiliation ()
11th Author's Name  
11th Author's Affiliation ()
12th Author's Name  
12th Author's Affiliation ()
13th Author's Name  
13th Author's Affiliation ()
14th Author's Name  
14th Author's Affiliation ()
15th Author's Name  
15th Author's Affiliation ()
16th Author's Name  
16th Author's Affiliation ()
17th Author's Name  
17th Author's Affiliation ()
18th Author's Name  
18th Author's Affiliation ()
19th Author's Name  
19th Author's Affiliation ()
20th Author's Name  
20th Author's Affiliation ()
21st Author's Name  
21st Author's Affiliation ()
22nd Author's Name  
22nd Author's Affiliation ()
23rd Author's Name  
23rd Author's Affiliation ()
24th Author's Name  
24th Author's Affiliation ()
25th Author's Name  
25th Author's Affiliation ()
26th Author's Name / /
26th Author's Affiliation ()
()
27th Author's Name / /
27th Author's Affiliation ()
()
28th Author's Name / /
28th Author's Affiliation ()
()
29th Author's Name / /
29th Author's Affiliation ()
()
30th Author's Name / /
30th Author's Affiliation ()
()
31st Author's Name / /
31st Author's Affiliation ()
()
32nd Author's Name / /
32nd Author's Affiliation ()
()
33rd Author's Name / /
33rd Author's Affiliation ()
()
34th Author's Name / /
34th Author's Affiliation ()
()
35th Author's Name / /
35th Author's Affiliation ()
()
36th Author's Name / /
36th Author's Affiliation ()
()
Speaker Author-1 
Date Time 2010-01-28 10:05:00 
Presentation Time 10 minutes 
Registration for MI 
Paper # MI2009-76 
Volume (vol) vol.109 
Number (no) no.407 
Page pp.7-12 
#Pages 6 
Date of Issue 2010-01-21 (MI) 

[Return to Top Page]

[Return to IEICE Web Page]
The Institute of Electronics, Information and Communication Engineers (IEICE), Japan