Paper Abstract and Keywords |
Presentation |
2010-03-09 10:15
Difference in odor discrimination between presynaptic and postsynaptic inhibition in the Drosophila olfactory circuit Ryota Satoh, Masafumi Oizumi (Univ. of Tokyo), Hokto Kazama (Harvard Medical School), Masato Okada (Univ. of Tokyo/RIKEN) NC2009-89 |
Abstract |
(in Japanese) |
(See Japanese page) |
(in English) |
A recent investigation has indicated that lateral presynaptic inhibitory input mediates gain control in the Drosophila antennal lobe. They have shown that the lateral presynaptic inhibitory input to projection neurons (PNs) roughly scales with total feedforward input from olfactory receptor neurons (ORNs). We investigate how this gain control mechanism contributes to the discriminability of odors in responses of PNs by simulating a network model of the Drosophila antennal lobe. To clarify the functional significance of ‘pre’-synaptic inhibitory gain control mechanism, which indirectly inhibits PNs by regulating the release probability of the synapse between ORNs and PNs, we also consider the case that inhibition acts ‘post’-synaptically by directly decreasing the membrane potential of PNs. We first show that the presynaptic global inhibition can sharpen the odour tuning of PNs whereas the postsynaptic global inhibition does not change it. We next demonstrate that the presynaptic gain control enhances the accuracy of odorant discrimination although the postsynaptic gain control only diminishes it. Finally, we discuss the reason why the odor discriminability can be enhanced by this presynaptic gain control mechanism. |
Keyword |
(in Japanese) |
(See Japanese page) |
(in English) |
Drosophila / Olfaction / Antennal lobe / Presynaptic inhibition / Postsynaptic inhibition / / / |
Reference Info. |
IEICE Tech. Rep., vol. 109, no. 461, NC2009-89, pp. 13-18, March 2010. |
Paper # |
NC2009-89 |
Date of Issue |
2010-03-02 (NC) |
ISSN |
Print edition: ISSN 0913-5685 Online edition: ISSN 2432-6380 |
Copyright and reproduction |
All rights are reserved and no part of this publication may be reproduced or transmitted in any form or by any means, electronic or mechanical, including photocopy, recording, or any information storage and retrieval system, without permission in writing from the publisher. Notwithstanding, instructors are permitted to photocopy isolated articles for noncommercial classroom use without fee. (License No.: 10GA0019/12GB0052/13GB0056/17GB0034/18GB0034) |
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NC2009-89 |
Conference Information |
Committee |
NC MBE |
Conference Date |
2010-03-09 - 2010-03-11 |
Place (in Japanese) |
(See Japanese page) |
Place (in English) |
Tamagawa University |
Topics (in Japanese) |
(See Japanese page) |
Topics (in English) |
General |
Paper Information |
Registration To |
NC |
Conference Code |
2010-03-NC-MBE |
Language |
Japanese |
Title (in Japanese) |
(See Japanese page) |
Sub Title (in Japanese) |
(See Japanese page) |
Title (in English) |
Difference in odor discrimination between presynaptic and postsynaptic inhibition in the Drosophila olfactory circuit |
Sub Title (in English) |
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Drosophila |
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Olfaction |
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Antennal lobe |
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Presynaptic inhibition |
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Postsynaptic inhibition |
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1st Author's Name |
Ryota Satoh |
1st Author's Affiliation |
The University of Tokyo (Univ. of Tokyo) |
2nd Author's Name |
Masafumi Oizumi |
2nd Author's Affiliation |
The University of Tokyo (Univ. of Tokyo) |
3rd Author's Name |
Hokto Kazama |
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Harvard Medical School (Harvard Medical School) |
4th Author's Name |
Masato Okada |
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The University of Tokyo/RIKEN Brain Science Institute (Univ. of Tokyo/RIKEN) |
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Speaker |
Author-1 |
Date Time |
2010-03-09 10:15:00 |
Presentation Time |
25 minutes |
Registration for |
NC |
Paper # |
NC2009-89 |
Volume (vol) |
vol.109 |
Number (no) |
no.461 |
Page |
pp.13-18 |
#Pages |
6 |
Date of Issue |
2010-03-02 (NC) |