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Paper Abstract and Keywords
Presentation 2010-11-19 15:20
Parameter Space Analysis of a Myocardial Cell Model for Drug Effect Estimation
Manabu Fujii (Kyoto Univ.), Takao Shimayoshi (ASTEM RI/Kyoto), Jianyin Lu (Kyoto Univ.), Keiichi Asakura (Nippon Shinyaku), Akira Amano (Ritsumeikan Univ.), Tetsuya Matsuda (Kyoto Univ.) MBE2010-52
Abstract (in Japanese) (See Japanese page) 
(in English) It is of importance to estimate the activity ratios of cardiac cellular ion channels for detecting side effects of drugs under development.
A myocardial cell model enables the estimation of the activity ratios by reproducing experimental cardiac cellular action potential (AP) recordings with varied parameters.
We analized the relationship between parameters and outputs of the model.
Results from the analysis of the distribution of similar AP recordings and myocardial contractility in parameter space show the difficulty in estimating activity ratios of ion channels based on AP recordings or myocardial contractility alone.
However, they also show the possibility to improve the estimation accuracy by the combined use of AP recordings and myocardial contractility.
Keyword (in Japanese) (See Japanese page) 
(in English) myocardial cell model / drug effect estimation / ion channel / action potential / myocardial contractility / parameter space analysis / /  
Reference Info. IEICE Tech. Rep., vol. 110, no. 294, MBE2010-52, pp. 93-97, Nov. 2010.
Paper # MBE2010-52 
Date of Issue 2010-11-11 (MBE) 
ISSN Print edition: ISSN 0913-5685    Online edition: ISSN 2432-6380
Copyright
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reproduction		 All rights are reserved and no part of this publication may be reproduced or transmitted in any form or by any means, electronic or mechanical, including photocopy, recording, or any information storage and retrieval system, without permission in writing from the publisher. Notwithstanding, instructors are permitted to photocopy isolated articles for noncommercial classroom use without fee. (License No.: 10GA0019/12GB0052/13GB0056/17GB0034/18GB0034)
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Conference Information
Committee MBE NC  
Conference Date 2010-11-18 - 2010-11-19 
Place (in Japanese) (See Japanese page) 
Place (in English) Tohoku University 
Topics (in Japanese) (See Japanese page) 
Topics (in English) BCI/BMI, NC and MBE 
Paper Information
Registration To MBE 
Conference Code 2010-11-MBE-NC 
Language Japanese 
Title (in Japanese) (See Japanese page) 
Sub Title (in Japanese) (See Japanese page) 
Title (in English) Parameter Space Analysis of a Myocardial Cell Model for Drug Effect Estimation 
Sub Title (in English)  
Keyword(1) myocardial cell model  
Keyword(2) drug effect estimation  
Keyword(3) ion channel  
Keyword(4) action potential  
Keyword(5) myocardial contractility  
Keyword(6) parameter space analysis  
Keyword(7)  
Keyword(8)  
1st Author's Name Manabu Fujii  
1st Author's Affiliation Kyoto University (Kyoto Univ.)
2nd Author's Name Takao Shimayoshi  
2nd Author's Affiliation ASTEM Research Institute of Kyoto (ASTEM RI/Kyoto)
3rd Author's Name Jianyin Lu  
3rd Author's Affiliation Kyoto University (Kyoto Univ.)
4th Author's Name Keiichi Asakura  
4th Author's Affiliation Nippon Shinyaku Co,. Ltd. (Nippon Shinyaku)
5th Author's Name Akira Amano  
5th Author's Affiliation Ritsumeikan University (Ritsumeikan Univ.)
6th Author's Name Tetsuya Matsuda  
6th Author's Affiliation Kyoto University (Kyoto Univ.)
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Speaker Author-1 
Date Time 2010-11-19 15:20:00 
Presentation Time 25 minutes 
Registration for MBE 
Paper # MBE2010-52 
Volume (vol) vol.110 
Number (no) no.294 
Page pp.93-97 
#Pages 5 
Date of Issue 2010-11-11 (MBE) 

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