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| Presentation | 2011-03-07 17:25 Signal transduction mechanisms for the regulation of ATP release during ischemia in cardiomyocytes Satohiko Kunugi, Sadahiro Iwabuchi, Daisuke Matsuyama, Koichi Kawahara (Hokkaido Univ.)  MBE2010-112 |
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| Abstract | (in Japanese) | (See Japanese page) |
| (in English) | A variety of cellular mechanisms are involved in the release of intracellular ATP in cardiomyocytes. It is reported that the maxi-anion channel is the major pathway for ATP release in the early stage of ischemia, while ATP is also released through hemichannels during ischemia. Recent findings have revealed that ATP works as one of the extracellular signaling molecules responsible for intercellular communications. However, functional relationships not only between ATP release via maxi-anion channels and that via hemichannels, but also between the quantity of ATP released and ischemia/reperfusion injury in cardiomyocytes are unknown. In this study, we aimed at clarifying the intracellular signal transduction system regulating ATP release during ischemia in cultured cardiomyocytes. The present study suggested that there existed a negative-feedback regulatory mechanism for the maxi-anion channel-derived ATP-induced suppression of further ATP release via hemichannels during ischemia. | |
| Keyword | (in Japanese) | (See Japanese page) |
| (in English) | ischemia / reperfusion / cardiomyocytes / ATP / maxi-anion channel / hemichannels / / | |
| Reference Info. | IEICE Tech. Rep., vol. 110, no. 460, MBE2010-112, pp. 53-56, March 2011. | |
| Paper # | MBE2010-112 | |
| Date of Issue | 2011-02-28 (MBE) | |
| ISSN | Print edition: ISSN 0913-5685 Online edition: ISSN 2432-6380 | |
| Copyright and reproduction |
All rights are reserved and no part of this publication may be reproduced or transmitted in any form or by any means, electronic or mechanical, including photocopy, recording, or any information storage and retrieval system, without permission in writing from the publisher. Notwithstanding, instructors are permitted to photocopy isolated articles for noncommercial classroom use without fee. (License No.: 10GA0019/12GB0052/13GB0056/17GB0034/18GB0034) | |
| Download PDF | MBE2010-112 |
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| Conference Information | |
| Committee | NC MBE |
| Conference Date | 2011-03-07 - 2011-03-09 |
| Place (in Japanese) | (See Japanese page) |
| Place (in English) | Tamagawa University |
| Topics (in Japanese) | (See Japanese page) |
| Topics (in English) | |
| Paper Information | |
| Registration To | MBE |
| Conference Code | 2011-03-NC-MBE |
| Language | Japanese |
| Title (in Japanese) | (See Japanese page) |
| Sub Title (in Japanese) | (See Japanese page) |
| Title (in English) | Signal transduction mechanisms for the regulation of ATP release during ischemia in cardiomyocytes |
| Sub Title (in English) | |
| Keyword(1) | ischemia |
| Keyword(2) | reperfusion |
| Keyword(3) | cardiomyocytes |
| Keyword(4) | ATP |
| Keyword(5) | maxi-anion channel |
| Keyword(6) | hemichannels |
| Keyword(7) | |
| Keyword(8) | |
| 1st Author's Name | Satohiko Kunugi |
| 1st Author's Affiliation | Hokkaido University (Hokkaido Univ.) |
| 2nd Author's Name | Sadahiro Iwabuchi |
| 2nd Author's Affiliation | Hokkaido University (Hokkaido Univ.) |
| 3rd Author's Name | Daisuke Matsuyama |
| 3rd Author's Affiliation | Hokkaido University (Hokkaido Univ.) |
| 4th Author's Name | Koichi Kawahara |
| 4th Author's Affiliation | Hokkaido University (Hokkaido Univ.) |
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| Speaker | Author-1 |
| Date Time | 2011-03-07 17:25:00 |
| Presentation Time | 25 minutes |
| Registration for | MBE |
| Paper # | MBE2010-112 |
| Volume (vol) | vol.110 |
| Number (no) | no.460 |
| Page | pp.53-56 |
| #Pages | 4 |
| Date of Issue | 2011-02-28 (MBE) |
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