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Paper Abstract and Keywords
Presentation 2012-01-26 14:45
Evaluation of Magnetic Markers for Liquid-Phase Magnetic Immunoassays Using SQUID
Hideki Watanabe, Yuichi Higuchi, Shinobu Uchida, Masaaki Matsuo, Takashi Yoshida, Keiji Enpuku (Kyushu Univ.) SCE2011-26
Abstract (in Japanese) (See Japanese page) 
(in English) We have been developing a liquid-phase immunoassay using SQUID and magnetic markers. We investigated the magnetic properties of the marker in order to quantitatively evaluate the immunoassay results. Magnetic marker usually consists of agglomerate of nanoparticles, i.e., magnetic cluster, whose magnetic properties strongly depend on its size and magnetic interaction between nanoparticles. Taking account of the distribution of cluster size in practical makers, we tentatively assumed that the magnetic marker consisted of two types of magnetic cluster. One is a large magnetic cluster whose magnetic properties in liquid are dominated by the Brownian relaxation. The other is a small cluster whose magnetic properties are dominated by the Neel relaxation. We distinguished these two types of markers by analyzing the experimental M-H curve measured in liquid and solid phases. Because the evaluation results reasonably agreed with the immunoassay results, it became possible to quantitatively evaluate the immunoassay results from magnetic properties of the marker.
Keyword (in Japanese) (See Japanese page) 
(in English) SQUID / Magnetic Marker / Magnetic Nanoparticle / Biosensor / / / /  
Reference Info. IEICE Tech. Rep., vol. 111, no. 418, SCE2011-26, pp. 41-46, Jan. 2012.
Paper # SCE2011-26 
Date of Issue 2012-01-19 (SCE) 
ISSN Print edition: ISSN 0913-5685    Online edition: ISSN 2432-6380
Copyright
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reproduction		 All rights are reserved and no part of this publication may be reproduced or transmitted in any form or by any means, electronic or mechanical, including photocopy, recording, or any information storage and retrieval system, without permission in writing from the publisher. Notwithstanding, instructors are permitted to photocopy isolated articles for noncommercial classroom use without fee. (License No.: 10GA0019/12GB0052/13GB0056/17GB0034/18GB0034)
Download PDF SCE2011-26

Conference Information
Committee SCE  
Conference Date 2012-01-26 - 2012-01-26 
Place (in Japanese) (See Japanese page) 
Place (in English) Kikai-Shinko-Kaikan Bldg. B3-2 
Topics (in Japanese) (See Japanese page) 
Topics (in English) Superconducting sensing technologies and their applications, etc. 
Paper Information
Registration To SCE 
Conference Code 2012-01-SCE 
Language Japanese 
Title (in Japanese) (See Japanese page) 
Sub Title (in Japanese) (See Japanese page) 
Title (in English) Evaluation of Magnetic Markers for Liquid-Phase Magnetic Immunoassays Using SQUID 
Sub Title (in English)  
Keyword(1) SQUID  
Keyword(2) Magnetic Marker  
Keyword(3) Magnetic Nanoparticle  
Keyword(4) Biosensor  
Keyword(5)  
Keyword(6)  
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1st Author's Name Hideki Watanabe  
1st Author's Affiliation Kyushu University (Kyushu Univ.)
2nd Author's Name Yuichi Higuchi  
2nd Author's Affiliation Kyushu University (Kyushu Univ.)
3rd Author's Name Shinobu Uchida  
3rd Author's Affiliation Kyushu University (Kyushu Univ.)
4th Author's Name Masaaki Matsuo  
4th Author's Affiliation Kyushu University (Kyushu Univ.)
5th Author's Name Takashi Yoshida  
5th Author's Affiliation Kyushu University (Kyushu Univ.)
6th Author's Name Keiji Enpuku  
6th Author's Affiliation Kyushu University (Kyushu Univ.)
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Speaker Author-1 
Date Time 2012-01-26 14:45:00 
Presentation Time 25 minutes 
Registration for SCE 
Paper # SCE2011-26 
Volume (vol) vol.111 
Number (no) no.418 
Page pp.41-46 
#Pages 6 
Date of Issue 2012-01-19 (SCE) 

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