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| Presentation | 2013-01-24 10:40 Measurement of the specific adsorption of biotinylated microbubbles using a quarts crystal microbalance Takashige Muramoto, Ryosuke Shimoya, Kenji Yoshida, Yoshiaki Watanabe (Doshisha Univ.)  US2012-88 |
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| Abstract | (in Japanese) | (See Japanese page) |
| (in English) | In addition to the application of microbubbles as contrast agent for diagnostic ultrasound, microbubbles are also applied as the drug carrier in drug delivery system. Targeting microbubbles enables to get the strong signal on ultrasound tissue imaging and deliver drug to the objective site. In this report, we prepared biotinylated mirobubbles and evaluated the specific adsorption of microbubbles with a quartz crystal sensor. When a substance deposited on the QCM electrode, the resonance frequency decreases. By tracking resonance frequency, we can observe attachment of microbubbles. We attached Biotin-SAMs on the QCM electrode and monitored binding behavior of streptavidin and biotinylated microbubles. The resonance frequency declined rapidly by biotinylated microbubbles compared to the case of normal microbubbles. That indicates this method is effective to evaluate the specific adsorption of microbubbles. | |
| Keyword | (in Japanese) | (See Japanese page) |
| (in English) | Ultrasound / Microbubble / Specific adsorption / Piezoelectric sensor / Drug Delivery System / / / | |
| Reference Info. | IEICE Tech. Rep., vol. 112, no. 387, US2012-88, pp. 1-6, Jan. 2013. | |
| Paper # | US2012-88 | |
| Date of Issue | 2013-01-17 (US) | |
| ISSN | Print edition: ISSN 0913-5685 Online edition: ISSN 2432-6380 | |
| Copyright and reproduction |
All rights are reserved and no part of this publication may be reproduced or transmitted in any form or by any means, electronic or mechanical, including photocopy, recording, or any information storage and retrieval system, without permission in writing from the publisher. Notwithstanding, instructors are permitted to photocopy isolated articles for noncommercial classroom use without fee. (License No.: 10GA0019/12GB0052/13GB0056/17GB0034/18GB0034) | |
| Download PDF | US2012-88 |
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| Conference Information | |
| Committee | US EA |
| Conference Date | 2013-01-24 - 2013-01-25 |
| Place (in Japanese) | (See Japanese page) |
| Place (in English) | Kambaikan, Doshisha Univ. |
| Topics (in Japanese) | (See Japanese page) |
| Topics (in English) | [Joint Meeting on Acoustics and Ultrasonics Subsociety] Engineering/Electro Acoustics, Ultrasonic and Underwater Acoustics，and Related Topics |
| Paper Information | |
| Registration To | US |
| Conference Code | 2013-01-US-EA |
| Language | Japanese |
| Title (in Japanese) | (See Japanese page) |
| Sub Title (in Japanese) | (See Japanese page) |
| Title (in English) | Measurement of the specific adsorption of biotinylated microbubbles using a quarts crystal microbalance |
| Sub Title (in English) | |
| Keyword(1) | Ultrasound |
| Keyword(2) | Microbubble |
| Keyword(3) | Specific adsorption |
| Keyword(4) | Piezoelectric sensor |
| Keyword(5) | Drug Delivery System |
| Keyword(6) | |
| Keyword(7) | |
| Keyword(8) | |
| 1st Author's Name | Takashige Muramoto |
| 1st Author's Affiliation | Doshisha University (Doshisha Univ.) |
| 2nd Author's Name | Ryosuke Shimoya |
| 2nd Author's Affiliation | Doshisha University (Doshisha Univ.) |
| 3rd Author's Name | Kenji Yoshida |
| 3rd Author's Affiliation | Doshisha University (Doshisha Univ.) |
| 4th Author's Name | Yoshiaki Watanabe |
| 4th Author's Affiliation | Doshisha University (Doshisha Univ.) |
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| Speaker | Author-1 |
| Date Time | 2013-01-24 10:40:00 |
| Presentation Time | 20 minutes |
| Registration for | US |
| Paper # | US2012-88 |
| Volume (vol) | vol.112 |
| Number (no) | no.387 |
| Page | pp.1-6 |
| #Pages | 6 |
| Date of Issue | 2013-01-17 (US) |
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