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Paper Abstract and Keywords
Presentation 2013-06-24 14:00
Application of quartz crystal microbalance to the evaluation system for specific adsorption of targeted microbubbles -- Choice of optimal parameter for the measurement --
Ryosuke Shimoya, Takashige Muramoto, Kenji Yoshida, Yoshiaki Watanabe (Doshisha Univ.) US2013-17
Abstract (in Japanese) (See Japanese page) 
(in English) Targeted microbubbles which can attach specifically to the objective site would be applied to the contrast agent in molecular imaging and the drug carrier in drug delivery system. For practical use of the microbubbles, a method of evaluation for specific adsorption of microbubbles using quartz crystal microbalance (QCM) is proposed. In this report, streptavidin layer as the targeting site was formed on the QCM electrode with Biotin-SAM. Moreover, biotinylated microbubbles were attached to the targeting site via streptavidin-biotin bond. Frequencies of f1 and f2 were determined where conductance of QCM is half of maximum. The changes of f1 and f2 caused by specific adsorption of bubbles were measured. Un-biotinylated microbubbles and biotinylated lipid without bubbles also were examined as controls. Comparison of those results possibly indicated that the change of f1 and f2 was affected by microbubbles and by the specific adsorption of phospholipid respectively.
Keyword (in Japanese) (See Japanese page) 
(in English) QCM / resonant characteristics / streptavidin-biotin bond / targeting ability / microbubbles / / /  
Reference Info. IEICE Tech. Rep., vol. 113, no. 107, US2013-17, pp. 13-17, June 2013.
Paper # US2013-17 
Date of Issue 2013-06-17 (US) 
ISSN Print edition: ISSN 0913-5685    Online edition: ISSN 2432-6380
Copyright
and
reproduction		 All rights are reserved and no part of this publication may be reproduced or transmitted in any form or by any means, electronic or mechanical, including photocopy, recording, or any information storage and retrieval system, without permission in writing from the publisher. Notwithstanding, instructors are permitted to photocopy isolated articles for noncommercial classroom use without fee. (License No.: 10GA0019/12GB0052/13GB0056/17GB0034/18GB0034)
Download PDF US2013-17

Conference Information
Committee US  
Conference Date 2013-06-24 - 2013-06-24 
Place (in Japanese) (See Japanese page) 
Place (in English) Inst. Indust. Sci, Univ. of Tokyo 
Topics (in Japanese) (See Japanese page) 
Topics (in English) Ultrasonics in Medicine, Acoustic Imaging, General 
Paper Information
Registration To US 
Conference Code 2013-06-US 
Language Japanese 
Title (in Japanese) (See Japanese page) 
Sub Title (in Japanese) (See Japanese page) 
Title (in English) Application of quartz crystal microbalance to the evaluation system for specific adsorption of targeted microbubbles 
Sub Title (in English) Choice of optimal parameter for the measurement 
Keyword(1) QCM  
Keyword(2) resonant characteristics  
Keyword(3) streptavidin-biotin bond  
Keyword(4) targeting ability  
Keyword(5) microbubbles  
Keyword(6)  
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1st Author's Name Ryosuke Shimoya  
1st Author's Affiliation Doshisha University (Doshisha Univ.)
2nd Author's Name Takashige Muramoto  
2nd Author's Affiliation Doshisha University (Doshisha Univ.)
3rd Author's Name Kenji Yoshida  
3rd Author's Affiliation Doshisha University (Doshisha Univ.)
4th Author's Name Yoshiaki Watanabe  
4th Author's Affiliation Doshisha University (Doshisha Univ.)
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Speaker Author-1 
Date Time 2013-06-24 14:00:00 
Presentation Time 30 minutes 
Registration for US 
Paper # US2013-17 
Volume (vol) vol.113 
Number (no) no.107 
Page pp.13-17 
#Pages 5 
Date of Issue 2013-06-17 (US) 

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