Information: Join today and make your research activities more affordable! Technical workshop participation fees and annual registration fees are available at member rates.
Notice: [Important] Announcement of Changes to Registration Fee Payment and Manuscript Upload Procedures for IEICE Technical Meetings
IEICE Technical Committee Submission System
Conference Paper's Information		 Online Proceedings
[Sign in]
Tech. Rep. Archives
 Go Top Page Go Previous   [Japanese] / [English] 

Paper Abstract and Keywords
Presentation 2013-12-21 16:45
An MR Diffusion Tensor Fiber Tracking Study on the Disruption of Cerebral White Matter Integrity in Alzheimer's Disease
Akifumi Hisada, Tetsuo Kobayashi (Kyoto Univ.), Takashi Yamazaki, Ken Nagata (Research Institute for Brain and Blood Vesseks-Akita) MBE2013-90
Abstract (in Japanese) (See Japanese page) 
(in English) The number of people with symptoms with dementia is now rapidly increasing in Japan, and the number of elderly people thought to be increasing more and more in the future. Therefore, evaluating dementia subjectively is necessary for early detection and treatment. In this paper, we analyzed Alzheimer's disease, which is one major form of dementia, by using tractography in cerebral white matter. Magnetic resonance diffusion tensor images (MR-DTIs) were acquired in 17 patients with mild Alzheimer’s disease, 17 patients with moderate Alzheimer’s disease, and 17 age- and sex-matched healthy comparison subjects. We selected regions of interests in the posterior thalamic radiation (PTR), anterior and superior corona radiata (ACR and SCR), cingulum (CG), and superior longitudinal fasciculus (SLF) and used the tractography to compare the number of fibers tracked and mean and standard deviation of fractional anisotropy, mean diffusivity, and curvature of fibers. As the result of the comparison, we found that there were significant and marginally significant differences among all groups and between two hemispheres so well. In particular, we found that the mean MD of left PTR, mean FA of right SCR, and mean curvature of SLF were influenced by the progression of Alzheimer’s disease. These results suggest the possibility of subjective evaluation of Alzheimer's disease.
Keyword (in Japanese) (See Japanese page) 
(in English) Alzheimer's disease / MRI / MRDTI / tractography / fractional anisotropy / / /  
Reference Info. IEICE Tech. Rep., vol. 113, no. 373, MBE2013-90, pp. 81-86, Dec. 2013.
Paper # MBE2013-90 
Date of Issue 2013-12-14 (MBE) 
ISSN Print edition: ISSN 0913-5685    Online edition: ISSN 2432-6380
Copyright
and
reproduction		 All rights are reserved and no part of this publication may be reproduced or transmitted in any form or by any means, electronic or mechanical, including photocopy, recording, or any information storage and retrieval system, without permission in writing from the publisher. Notwithstanding, instructors are permitted to photocopy isolated articles for noncommercial classroom use without fee. (License No.: 10GA0019/12GB0052/13GB0056/17GB0034/18GB0034)
Download PDF MBE2013-90

Conference Information
Committee NC MBE  
Conference Date 2013-12-21 - 2013-12-21 
Place (in Japanese) (See Japanese page) 
Place (in English) Gifu University 
Topics (in Japanese) (See Japanese page) 
Topics (in English)  
Paper Information
Registration To MBE 
Conference Code 2013-12-NC-MBE 
Language Japanese 
Title (in Japanese) (See Japanese page) 
Sub Title (in Japanese) (See Japanese page) 
Title (in English) An MR Diffusion Tensor Fiber Tracking Study on the Disruption of Cerebral White Matter Integrity in Alzheimer's Disease 
Sub Title (in English) * 
Keyword(1) Alzheimer's disease  
Keyword(2) MRI  
Keyword(3) MRDTI  
Keyword(4) tractography  
Keyword(5) fractional anisotropy  
Keyword(6)  
Keyword(7)  
Keyword(8)  
1st Author's Name Akifumi Hisada  
1st Author's Affiliation Kyoto University (Kyoto Univ.)
2nd Author's Name Tetsuo Kobayashi  
2nd Author's Affiliation Kyoto University (Kyoto Univ.)
3rd Author's Name Takashi Yamazaki  
3rd Author's Affiliation Research Institute for Brain and Blood Vesseks-Akita (Research Institute for Brain and Blood Vesseks-Akita)
4th Author's Name Ken Nagata  
4th Author's Affiliation Research Institute for Brain and Blood Vesseks-Akita (Research Institute for Brain and Blood Vesseks-Akita)
5th Author's Name  
5th Author's Affiliation ()
6th Author's Name  
6th Author's Affiliation ()
7th Author's Name  
7th Author's Affiliation ()
8th Author's Name  
8th Author's Affiliation ()
9th Author's Name  
9th Author's Affiliation ()
10th Author's Name  
10th Author's Affiliation ()
11th Author's Name  
11th Author's Affiliation ()
12th Author's Name  
12th Author's Affiliation ()
13th Author's Name  
13th Author's Affiliation ()
14th Author's Name  
14th Author's Affiliation ()
15th Author's Name  
15th Author's Affiliation ()
16th Author's Name  
16th Author's Affiliation ()
17th Author's Name  
17th Author's Affiliation ()
18th Author's Name  
18th Author's Affiliation ()
19th Author's Name  
19th Author's Affiliation ()
20th Author's Name  
20th Author's Affiliation ()
21st Author's Name  
21st Author's Affiliation ()
22nd Author's Name  
22nd Author's Affiliation ()
23rd Author's Name  
23rd Author's Affiliation ()
24th Author's Name  
24th Author's Affiliation ()
25th Author's Name  
25th Author's Affiliation ()
26th Author's Name / /
26th Author's Affiliation ()
()
27th Author's Name / /
27th Author's Affiliation ()
()
28th Author's Name / /
28th Author's Affiliation ()
()
29th Author's Name / /
29th Author's Affiliation ()
()
30th Author's Name / /
30th Author's Affiliation ()
()
31st Author's Name / /
31st Author's Affiliation ()
()
32nd Author's Name / /
32nd Author's Affiliation ()
()
33rd Author's Name / /
33rd Author's Affiliation ()
()
34th Author's Name / /
34th Author's Affiliation ()
()
35th Author's Name / /
35th Author's Affiliation ()
()
36th Author's Name / /
36th Author's Affiliation ()
()
Speaker Author-1 
Date Time 2013-12-21 16:45:00 
Presentation Time 25 minutes 
Registration for MBE 
Paper # MBE2013-90 
Volume (vol) vol.113 
Number (no) no.373 
Page pp.81-86 
#Pages 6 
Date of Issue 2013-12-14 (MBE) 

[Return to Top Page]

[Return to IEICE Web Page]
The Institute of Electronics, Information and Communication Engineers (IEICE), Japan