Paper Abstract and Keywords |
Presentation |
2015-06-25 13:45
Evaluation of the role of ipsi-lateral feedback and commissural inhibition in the bilateral neuronal circuit of oculomotor neural integrator Keiichiro Inagaki, Yutaka Hirata (Chubu Univ.) NC2015-5 |
Abstract |
(in Japanese) |
(See Japanese page) |
(in English) |
A conceptual neural mechanism achieving velocity to position integration is the oculomotor neural integrator (NI). Neurons in the nucleus of prepositus hypoglossi (NPH) in mammals and equivalently Area I (AI) in goldfish have been demonstrated to exhibit persistent activities relating to eye position. Ipsilateral positive feedback found in NPH and AI, and commissural inhibition between bilateral structures of these areas are proposed to be two candidate neuronal networks for the integration. However, how these networks contribute to generate persistent firing activities is still unknown. In the present study, we constructed a neuronal network model of the NI. Synaptic weights in the model are carefully tuned to reproduce saccades and post-saccadic stable eye positions, then either the synaptic weights of ipsilateral feedback connection or those of commissural inhibition are individually modified to see the effects on post-saccadic eye position drifts. Simulation results showed that persistent firing activity of integrator neurons is maintained mainly by the commissural inhibition, while the ipsilateral positive feedback contributes to determine the null eye position that is the asymptote when the NI is leaky. This is the first demonstration by a neuronal network model assigning specific and different roles to the ipsilateral positive feedback and the commissural inhibition in the NI. |
Keyword |
(in Japanese) |
(See Japanese page) |
(in English) |
oculomotor system / neural integrator / commissural inhibition / computer simulation / eye movement / / / |
Reference Info. |
IEICE Tech. Rep., vol. 115, no. 111, NC2015-5, pp. 63-68, June 2015. |
Paper # |
NC2015-5 |
Date of Issue |
2015-06-17 (NC) |
ISSN |
Print edition: ISSN 0913-5685 Online edition: ISSN 2432-6380 |
Copyright and reproduction |
All rights are reserved and no part of this publication may be reproduced or transmitted in any form or by any means, electronic or mechanical, including photocopy, recording, or any information storage and retrieval system, without permission in writing from the publisher. Notwithstanding, instructors are permitted to photocopy isolated articles for noncommercial classroom use without fee. (License No.: 10GA0019/12GB0052/13GB0056/17GB0034/18GB0034) |
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NC2015-5 |
Conference Information |
Committee |
NC IPSJ-BIO IBISML IPSJ-MPS |
Conference Date |
2015-06-23 - 2015-06-25 |
Place (in Japanese) |
(See Japanese page) |
Place (in English) |
Okinawa Institute of Science and Technology |
Topics (in Japanese) |
(See Japanese page) |
Topics (in English) |
Machine Learning Approach to Biodata Mining, and General |
Paper Information |
Registration To |
NC |
Conference Code |
2015-06-NC-BIO-IBISML-MPS |
Language |
Japanese |
Title (in Japanese) |
(See Japanese page) |
Sub Title (in Japanese) |
(See Japanese page) |
Title (in English) |
Evaluation of the role of ipsi-lateral feedback and commissural inhibition in the bilateral neuronal circuit of oculomotor neural integrator |
Sub Title (in English) |
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Keyword(1) |
oculomotor system |
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neural integrator |
Keyword(3) |
commissural inhibition |
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computer simulation |
Keyword(5) |
eye movement |
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1st Author's Name |
Keiichiro Inagaki |
1st Author's Affiliation |
Chubu University (Chubu Univ.) |
2nd Author's Name |
Yutaka Hirata |
2nd Author's Affiliation |
Chubu University (Chubu Univ.) |
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Speaker |
Author-1 |
Date Time |
2015-06-25 13:45:00 |
Presentation Time |
25 minutes |
Registration for |
NC |
Paper # |
NC2015-5 |
Volume (vol) |
vol.115 |
Number (no) |
no.111 |
Page |
pp.63-68 |
#Pages |
6 |
Date of Issue |
2015-06-17 (NC) |
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