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Paper Abstract and Keywords
Presentation 2016-01-19 13:20
Measurement of change in endogenous serotonin levels by PET dynamic analysis
Yoko Ikoma, Hiroyuki Takuwa, Asuka Nishino, Chie Seki, Jun Maeda (NIRS) MI2015-85
Abstract (in Japanese) (See Japanese page) 
(in English) The neurotransmitter, such as dopamine and serotonin, is related to depression, Parkinson disease, and other psychiatric or neurologic disorders. In the measurement of neuroreceptors using positron emission tomography (PET), the binding of administered radioligand to the receptors often competes with endogenous neurotransmitters. Therefore, an increase or decrease of the neurotransmitters in the synaptic cleft can be estimated from change in the binding of radioligand to the receptors. In this study, we targeted to the quantification of the change in the serotonin level, time-activity curves obtained by the PET dynamic scan were simulated using a compartment model including the administered radioligand and endogenous serotonin concentration. From these curves, we evaluated the analysis method for estimating the change in endogenous serotonin level, and validated the proposed method by small animal PET scans.
Keyword (in Japanese) (See Japanese page) 
(in English) Positron Emission Tomography / Compartment Model / Serotonin Receptor / Binding Potential / / / /  
Reference Info. IEICE Tech. Rep., vol. 115, no. 401, MI2015-85, pp. 65-68, Jan. 2016.
Paper # MI2015-85 
Date of Issue 2016-01-12 (MI) 
ISSN Print edition: ISSN 0913-5685    Online edition: ISSN 2432-6380
Copyright
and
reproduction		 All rights are reserved and no part of this publication may be reproduced or transmitted in any form or by any means, electronic or mechanical, including photocopy, recording, or any information storage and retrieval system, without permission in writing from the publisher. Notwithstanding, instructors are permitted to photocopy isolated articles for noncommercial classroom use without fee. (License No.: 10GA0019/12GB0052/13GB0056/17GB0034/18GB0034)
Download PDF MI2015-85

Conference Information
Committee MI  
Conference Date 2016-01-19 - 2016-01-20 
Place (in Japanese) (See Japanese page) 
Place (in English) Bunka Tenbusu Kan 
Topics (in Japanese) (See Japanese page) 
Topics (in English) General topics in medical imaging 
Paper Information
Registration To MI 
Conference Code 2016-01-MI 
Language Japanese 
Title (in Japanese) (See Japanese page) 
Sub Title (in Japanese) (See Japanese page) 
Title (in English) Measurement of change in endogenous serotonin levels by PET dynamic analysis 
Sub Title (in English)  
Keyword(1) Positron Emission Tomography  
Keyword(2) Compartment Model  
Keyword(3) Serotonin Receptor  
Keyword(4) Binding Potential  
Keyword(5)  
Keyword(6)  
Keyword(7)  
Keyword(8)  
1st Author's Name Yoko Ikoma  
1st Author's Affiliation National Institute of Radiological Sciences (NIRS)
2nd Author's Name Hiroyuki Takuwa  
2nd Author's Affiliation National Institute of Radiological Sciences (NIRS)
3rd Author's Name Asuka Nishino  
3rd Author's Affiliation National Institute of Radiological Sciences (NIRS)
4th Author's Name Chie Seki  
4th Author's Affiliation National Institute of Radiological Sciences (NIRS)
5th Author's Name Jun Maeda  
5th Author's Affiliation National Institute of Radiological Sciences (NIRS)
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Speaker Author-1 
Date Time 2016-01-19 13:20:00 
Presentation Time 40 minutes 
Registration for MI 
Paper # MI2015-85 
Volume (vol) vol.115 
Number (no) no.401 
Page pp.65-68 
#Pages 4 
Date of Issue 2016-01-12 (MI) 

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