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Paper Abstract and Keywords
Presentation 2016-05-20 11:20
The Detection of the Spatial Distribution of Small-molecule Drugs via Phase-sensitive Coherent Raman Microspectroscopy
Yuki Obara, Terumasa Ito, Kazuhiko Misawa (TUAT) LQE2016-12
Abstract (in Japanese) (See Japanese page) 
(in English) Two- or three-dimensional imaging of molecular species is quite important for life science research. Most drugs are small molecules ; however, these molecules are difficult to detect in biological materials because they cannot be labeled with chromophores. In this study, we demonstrated two dimensional imaging using intrinsic molecular vibrations. We developed novel phase-modulation in heterodyne-detected multiplex coherent Raman spectroscopy called quadrature-phase modulation and improved its spectral acquisition time. We successfully constructed a series of sliced two-dimensional images from vibrational Raman spectra. As a quasi-biomedical sample, droplets of small molecule drugs in an aqueous environment were employed.
Keyword (in Japanese) (See Japanese page) 
(in English) Coherent Raman / Phase modulation / / / / / /  
Reference Info. IEICE Tech. Rep., vol. 116, no. 52, LQE2016-12, pp. 55-58, May 2016.
Paper # LQE2016-12 
Date of Issue 2016-05-12 (LQE) 
ISSN Print edition: ISSN 0913-5685    Online edition: ISSN 2432-6380
Copyright
and
reproduction		 All rights are reserved and no part of this publication may be reproduced or transmitted in any form or by any means, electronic or mechanical, including photocopy, recording, or any information storage and retrieval system, without permission in writing from the publisher. Notwithstanding, instructors are permitted to photocopy isolated articles for noncommercial classroom use without fee. (License No.: 10GA0019/12GB0052/13GB0056/17GB0034/18GB0034)
Download PDF LQE2016-12

Conference Information
Committee LQE LSJ  
Conference Date 2016-05-19 - 2016-05-20 
Place (in Japanese) (See Japanese page) 
Place (in English)  
Topics (in Japanese) (See Japanese page) 
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Paper Information
Registration To LQE 
Conference Code 2016-05-LQE-LSJ 
Language Japanese 
Title (in Japanese) (See Japanese page) 
Sub Title (in Japanese) (See Japanese page) 
Title (in English) The Detection of the Spatial Distribution of Small-molecule Drugs via Phase-sensitive Coherent Raman Microspectroscopy 
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Keyword(1) Coherent Raman  
Keyword(2) Phase modulation  
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1st Author's Name Yuki Obara  
1st Author's Affiliation Tokyo University of Agriculture and Technology (TUAT)
2nd Author's Name Terumasa Ito  
2nd Author's Affiliation Tokyo University of Agriculture and Technology (TUAT)
3rd Author's Name Kazuhiko Misawa  
3rd Author's Affiliation Tokyo University of Agriculture and Technology (TUAT)
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Speaker Author-1 
Date Time 2016-05-20 11:20:00 
Presentation Time 25 minutes 
Registration for LQE 
Paper # LQE2016-12 
Volume (vol) vol.116 
Number (no) no.52 
Page pp.55-58 
#Pages 4 
Date of Issue 2016-05-12 (LQE) 

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