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Paper Abstract and Keywords
Presentation 2017-01-19 14:50
Effect of reaction conditions on magnetic signal from magnetic markers in liquid-phase immunoassays
Kota Nakamura, Yoshitsugu Takafuji, Kota Irie, Teruyoshi Sasayama, Takashi Yoshida, Keiji Enpuku (Kyushu Univ.) SCE2016-46
Abstract (in Japanese) (See Japanese page) 
(in English) We have been developing a highly sensitive liquid-phase detection of biological targets using magnetic markers and HTS SQUID. In order to realize high sensitivity of this technique, it is necessary to decrease signal from free markers, which we call blank signal, as well as to increase signal from bound markers. Previously, we showed that dispersion process after magnetization is effective to decrease blank signal. In this study, we optimized reaction conditions when the dispersion process was introduced, i.e., density of magnetic markers and time used for reaction. We also measured diameter of magnetic markers before and after the magnetization so as to study the aggregation caused by the magnetic field. It was found that magnetic field accelerated aggregation of magnetic markers. Then, we calculated blank signal from the agglomerate of free markers by taking into account their Brownian relaxation. The calculated blank signal reasonably agreed with the experimental result. Finally, we measured the Brownian relaxation time of the bound markers, and found that the measured time was shorter than the theoretical expectation.
Keyword (in Japanese) (See Japanese page) 
(in English) Biosensor / Brownian Relaxation / Immunoassay / Magnetic Marker / HTS SQUID / / /  
Reference Info. IEICE Tech. Rep., vol. 116, no. 410, SCE2016-46, pp. 43-48, Jan. 2017.
Paper # SCE2016-46 
Date of Issue 2017-01-12 (SCE) 
ISSN Print edition: ISSN 0913-5685    Online edition: ISSN 2432-6380
Copyright
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reproduction		 All rights are reserved and no part of this publication may be reproduced or transmitted in any form or by any means, electronic or mechanical, including photocopy, recording, or any information storage and retrieval system, without permission in writing from the publisher. Notwithstanding, instructors are permitted to photocopy isolated articles for noncommercial classroom use without fee. (License No.: 10GA0019/12GB0052/13GB0056/17GB0034/18GB0034)
Download PDF SCE2016-46

Conference Information
Committee SCE  
Conference Date 2017-01-19 - 2017-01-19 
Place (in Japanese) (See Japanese page) 
Place (in English) Kikai-Shinko-Kaikan Bldg. 
Topics (in Japanese) (See Japanese page) 
Topics (in English)  
Paper Information
Registration To SCE 
Conference Code 2017-01-SCE 
Language Japanese 
Title (in Japanese) (See Japanese page) 
Sub Title (in Japanese) (See Japanese page) 
Title (in English) Effect of reaction conditions on magnetic signal from magnetic markers in liquid-phase immunoassays 
Sub Title (in English)  
Keyword(1) Biosensor  
Keyword(2) Brownian Relaxation  
Keyword(3) Immunoassay  
Keyword(4) Magnetic Marker  
Keyword(5) HTS SQUID  
Keyword(6)  
Keyword(7)  
Keyword(8)  
1st Author's Name Kota Nakamura  
1st Author's Affiliation Kyushu University (Kyushu Univ.)
2nd Author's Name Yoshitsugu Takafuji  
2nd Author's Affiliation Kyushu University (Kyushu Univ.)
3rd Author's Name Kota Irie  
3rd Author's Affiliation Kyushu University (Kyushu Univ.)
4th Author's Name Teruyoshi Sasayama  
4th Author's Affiliation Kyushu University (Kyushu Univ.)
5th Author's Name Takashi Yoshida  
5th Author's Affiliation Kyushu University (Kyushu Univ.)
6th Author's Name Keiji Enpuku  
6th Author's Affiliation Kyushu University (Kyushu Univ.)
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Speaker Author-1 
Date Time 2017-01-19 14:50:00 
Presentation Time 25 minutes 
Registration for SCE 
Paper # SCE2016-46 
Volume (vol) vol.116 
Number (no) no.410 
Page pp.43-48 
#Pages 6 
Date of Issue 2017-01-12 (SCE) 

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