Paper Abstract and Keywords |
Presentation |
2017-03-14 15:25
Statistical Integrative Analysis of MicroRNA and Gene Takuya Oki, Yutaka Fukuoka (Kogakuin Univ.), Tomohiro Umezu, Junko Ohyashiki (Tokyo Med Univ.) MBE2016-101 |
Abstract |
(in Japanese) |
(See Japanese page) |
(in English) |
A microRNA (miRNA), which is a non-cording RNA, regulates genes, and recently its role in cancer attracts attention. Therefore, the number of studies on expression levels of miRNAs in cancer cells is increasing. Results of integrative analyses of miRNAs and mRNAs are largely affected by the size of the data used for the analysis. For a small sized data set, the numbers of significantly altered miRNAs and mRNAs tend to be small, indicating that no meaningful results are obtained. This study proposed a method for such small sized data sets. This method compared target genes of a miRNA as a group with randomly selected genes (back ground genes). We performed simulations to investigate the effectiveness of the proposed method. The simulation results indicated that the statistics used in the proposed method reflected the differences in the simulated data. Then, we applied it to real cancer data. Some groups of genes having functions related to cancer were extracted as significantly altered. These results suggest the effectiveness of the proposed the method. |
Keyword |
(in Japanese) |
(See Japanese page) |
(in English) |
MicroRNA (MiRNA) / Gene (MRNA) / Integrative Analysis / Cancer / / / / |
Reference Info. |
IEICE Tech. Rep., vol. 116, no. 520, MBE2016-101, pp. 91-94, March 2017. |
Paper # |
MBE2016-101 |
Date of Issue |
2017-03-06 (MBE) |
ISSN |
Print edition: ISSN 0913-5685 Online edition: ISSN 2432-6380 |
Copyright and reproduction |
All rights are reserved and no part of this publication may be reproduced or transmitted in any form or by any means, electronic or mechanical, including photocopy, recording, or any information storage and retrieval system, without permission in writing from the publisher. Notwithstanding, instructors are permitted to photocopy isolated articles for noncommercial classroom use without fee. (License No.: 10GA0019/12GB0052/13GB0056/17GB0034/18GB0034) |
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MBE2016-101 |
Conference Information |
Committee |
MBE NC |
Conference Date |
2017-03-13 - 2017-03-14 |
Place (in Japanese) |
(See Japanese page) |
Place (in English) |
Kikai-Shinko-Kaikan Bldg. |
Topics (in Japanese) |
(See Japanese page) |
Topics (in English) |
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Paper Information |
Registration To |
MBE |
Conference Code |
2017-03-MBE-NC |
Language |
Japanese |
Title (in Japanese) |
(See Japanese page) |
Sub Title (in Japanese) |
(See Japanese page) |
Title (in English) |
Statistical Integrative Analysis of MicroRNA and Gene |
Sub Title (in English) |
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Keyword(1) |
MicroRNA (MiRNA) |
Keyword(2) |
Gene (MRNA) |
Keyword(3) |
Integrative Analysis |
Keyword(4) |
Cancer |
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1st Author's Name |
Takuya Oki |
1st Author's Affiliation |
Kogakuin University (Kogakuin Univ.) |
2nd Author's Name |
Yutaka Fukuoka |
2nd Author's Affiliation |
Kogakuin University (Kogakuin Univ.) |
3rd Author's Name |
Tomohiro Umezu |
3rd Author's Affiliation |
Tokyo Medical University (Tokyo Med Univ.) |
4th Author's Name |
Junko Ohyashiki |
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Tokyo Medical University (Tokyo Med Univ.) |
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Speaker |
Author-1 |
Date Time |
2017-03-14 15:25:00 |
Presentation Time |
25 minutes |
Registration for |
MBE |
Paper # |
MBE2016-101 |
Volume (vol) |
vol.116 |
Number (no) |
no.520 |
Page |
pp.91-94 |
#Pages |
4 |
Date of Issue |
2017-03-06 (MBE) |
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