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Paper Abstract and Keywords
Presentation 2021-06-11 17:10
Behavior modification, and spontaneous activity and beta oscillation focused on the High Frequency Oscillation in latent period of kainic acid-induced epilepsy model
Hirofumi Arai, Ryusei Maeda, Kiyohisa Natsume (Kyutech) NLP2021-14 CCS2021-14
Abstract (in Japanese) (See Japanese page) 
(in English) High Frequency Oscillation (HFO) in human is observed as ripple of low frequency (80-250Hz), whereas patients with temporal lobe epilepsy is observed as fast ripple of high frequency (250-500Hz). Animal model of temporal lobe epilepsy is the kainate-treatment epilepsy model (KA group), in which chronic convulsions develop after an acute convulsion and latent period of about two weeks. We have investigated behavioral changes in the kainate group of the latent period, and looked for behaviors which capture behavioral detection before the onset of epilepsy. In addition, we have investigated neural circuit change in the kainate group of the latent period, and thought method after behavioral detection. In a previous study on behavior changes, we reported that the number of self-grooming increased after 8-10 days from kainate administration. In our previous study on neural circuit changes, we reported that in the hippocampal slices, occurrence rate of spontaneous activity is significantly high, acetylcholine agonist, carbachol induced beta oscillation (CIBO) frequency is significantly high, and it involves in high frequency of CIBO due to inhibitory neuron. In the present study of the behavior experiment, we conducted an adaptation for one week to remove the effects of handling before starting the experiment. These results suggested that the number of self-grooming excessively increased after 8-10 days from kainate administration. On the other hands, although Fast ripple is frequently observed in epilepsy, it is not clear whether HFO of spontaneous activity and CIBO is already altered in the CA3 region during latent period. Therefore, we focused on the HFO of spontaneous activity, and CIBO during latent period. As a result, Fast ripple power of spontaneous activity in kainate group was significantly higher than control group. Afterwards, Ripple, and Fast ripple power of CIBO was significantly lower than spontaneous activity, and HFO in spontaneous activity correlated with CIBO frequency.
These results suggest that in the hippocampal CA3 region of KA group, mossy fiber branches from DG to CA3’s Fast ripple cell, and as a result, Fast ripple power of spontaneous activity tends to be higher. In addition, after CIBO is induced, HFO power continues from spontaneous activity.
Keyword (in Japanese) (See Japanese page) 
(in English) epilepsy / kainate / hippocampal / HFO / CIBO / / /  
Reference Info. IEICE Tech. Rep., vol. 121, no. 61, NLP2021-14, pp. 67-72, June 2021.
Paper # NLP2021-14 
Date of Issue 2021-06-04 (NLP, CCS) 
ISSN Online edition: ISSN 2432-6380
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Conference Information
Committee NLP CCS  
Conference Date 2021-06-11 - 2021-06-11 
Place (in Japanese) (See Japanese page) 
Place (in English) Online 
Topics (in Japanese) (See Japanese page) 
Topics (in English)  
Paper Information
Registration To NLP 
Conference Code 2021-06-NLP-CCS 
Language Japanese 
Title (in Japanese) (See Japanese page) 
Sub Title (in Japanese) (See Japanese page) 
Title (in English) Behavior modification, and spontaneous activity and beta oscillation focused on the High Frequency Oscillation in latent period of kainic acid-induced epilepsy model 
Sub Title (in English)  
Keyword(1) epilepsy  
Keyword(2) kainate  
Keyword(3) hippocampal  
Keyword(4) HFO  
Keyword(5) CIBO  
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1st Author's Name Hirofumi Arai  
1st Author's Affiliation Kyushu Institute of Technology University (Kyutech)
2nd Author's Name Ryusei Maeda  
2nd Author's Affiliation Kyushu Institute of Technology University (Kyutech)
3rd Author's Name Kiyohisa Natsume  
3rd Author's Affiliation Kyushu Institute of Technology University (Kyutech)
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Speaker Author-1 
Date Time 2021-06-11 17:10:00 
Presentation Time 25 minutes 
Registration for NLP 
Paper # NLP2021-14, CCS2021-14 
Volume (vol) vol.121 
Number (no) no.61(NLP), no.62(CCS) 
Page pp.67-72 
#Pages
Date of Issue 2021-06-04 (NLP, CCS) 


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