Paper Abstract and Keywords |
Presentation |
2021-06-11 17:10
Behavior modification, and spontaneous activity and beta oscillation focused on the High Frequency Oscillation in latent period of kainic acid-induced epilepsy model Hirofumi Arai, Ryusei Maeda, Kiyohisa Natsume (Kyutech) NLP2021-14 CCS2021-14 |
Abstract |
(in Japanese) |
(See Japanese page) |
(in English) |
High Frequency Oscillation (HFO) in human is observed as ripple of low frequency (80-250Hz), whereas patients with temporal lobe epilepsy is observed as fast ripple of high frequency (250-500Hz). Animal model of temporal lobe epilepsy is the kainate-treatment epilepsy model (KA group), in which chronic convulsions develop after an acute convulsion and latent period of about two weeks. We have investigated behavioral changes in the kainate group of the latent period, and looked for behaviors which capture behavioral detection before the onset of epilepsy. In addition, we have investigated neural circuit change in the kainate group of the latent period, and thought method after behavioral detection. In a previous study on behavior changes, we reported that the number of self-grooming increased after 8-10 days from kainate administration. In our previous study on neural circuit changes, we reported that in the hippocampal slices, occurrence rate of spontaneous activity is significantly high, acetylcholine agonist, carbachol induced beta oscillation (CIBO) frequency is significantly high, and it involves in high frequency of CIBO due to inhibitory neuron. In the present study of the behavior experiment, we conducted an adaptation for one week to remove the effects of handling before starting the experiment. These results suggested that the number of self-grooming excessively increased after 8-10 days from kainate administration. On the other hands, although Fast ripple is frequently observed in epilepsy, it is not clear whether HFO of spontaneous activity and CIBO is already altered in the CA3 region during latent period. Therefore, we focused on the HFO of spontaneous activity, and CIBO during latent period. As a result, Fast ripple power of spontaneous activity in kainate group was significantly higher than control group. Afterwards, Ripple, and Fast ripple power of CIBO was significantly lower than spontaneous activity, and HFO in spontaneous activity correlated with CIBO frequency.
These results suggest that in the hippocampal CA3 region of KA group, mossy fiber branches from DG to CA3’s Fast ripple cell, and as a result, Fast ripple power of spontaneous activity tends to be higher. In addition, after CIBO is induced, HFO power continues from spontaneous activity. |
Keyword |
(in Japanese) |
(See Japanese page) |
(in English) |
epilepsy / kainate / hippocampal / HFO / CIBO / / / |
Reference Info. |
IEICE Tech. Rep., vol. 121, no. 61, NLP2021-14, pp. 67-72, June 2021. |
Paper # |
NLP2021-14 |
Date of Issue |
2021-06-04 (NLP, CCS) |
ISSN |
Online edition: ISSN 2432-6380 |
Copyright and reproduction |
All rights are reserved and no part of this publication may be reproduced or transmitted in any form or by any means, electronic or mechanical, including photocopy, recording, or any information storage and retrieval system, without permission in writing from the publisher. Notwithstanding, instructors are permitted to photocopy isolated articles for noncommercial classroom use without fee. (License No.: 10GA0019/12GB0052/13GB0056/17GB0034/18GB0034) |
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NLP2021-14 CCS2021-14 |
Conference Information |
Committee |
NLP CCS |
Conference Date |
2021-06-11 - 2021-06-11 |
Place (in Japanese) |
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Place (in English) |
Online |
Topics (in Japanese) |
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Paper Information |
Registration To |
NLP |
Conference Code |
2021-06-NLP-CCS |
Language |
Japanese |
Title (in Japanese) |
(See Japanese page) |
Sub Title (in Japanese) |
(See Japanese page) |
Title (in English) |
Behavior modification, and spontaneous activity and beta oscillation focused on the High Frequency Oscillation in latent period of kainic acid-induced epilepsy model |
Sub Title (in English) |
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Keyword(1) |
epilepsy |
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kainate |
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hippocampal |
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HFO |
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CIBO |
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1st Author's Name |
Hirofumi Arai |
1st Author's Affiliation |
Kyushu Institute of Technology University (Kyutech) |
2nd Author's Name |
Ryusei Maeda |
2nd Author's Affiliation |
Kyushu Institute of Technology University (Kyutech) |
3rd Author's Name |
Kiyohisa Natsume |
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Kyushu Institute of Technology University (Kyutech) |
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Speaker |
Author-1 |
Date Time |
2021-06-11 17:10:00 |
Presentation Time |
25 minutes |
Registration for |
NLP |
Paper # |
NLP2021-14, CCS2021-14 |
Volume (vol) |
vol.121 |
Number (no) |
no.61(NLP), no.62(CCS) |
Page |
pp.67-72 |
#Pages |
6 |
Date of Issue |
2021-06-04 (NLP, CCS) |
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