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Paper Abstract and Keywords
Presentation 2021-10-29 09:40
Computer simulations of colorectal tumor development
Riku Ichinohe (Tohoku Univ.), Norihiro Katayama (Tohoku Univ./Shokei Univ.), Mitsuyuki Nakao (Tohoku Univ.) MBE2021-23
Abstract (in Japanese) (See Japanese page) 
(in English) It is known that prevalence of colorectal cancer increases in work schedules that do not follow the circadian rhythm such as shift workers. In this study, we modeled the formation and maintenance mechanism of colonic epithelial tissue that repeats reorganization under the control of the central and peripheral circadian rhythm mechanisms. Based on this, we simulated the dynamics of tumor development by changing intensity of peripheral clock mechanism. Based on the results, we evaluate the carcinogenic risk and link it to proposals for lower-risk lifestyle habits.
Keyword (in Japanese) (See Japanese page) 
(in English) Circadian ryhthm / Cell cycle / Intestinal cancer / Mathematical model / / / /  
Reference Info. IEICE Tech. Rep., vol. 121, no. 222, MBE2021-23, pp. 32-36, Oct. 2021.
Paper # MBE2021-23 
Date of Issue 2021-10-21 (MBE) 
ISSN Online edition: ISSN 2432-6380
All rights are reserved and no part of this publication may be reproduced or transmitted in any form or by any means, electronic or mechanical, including photocopy, recording, or any information storage and retrieval system, without permission in writing from the publisher. Notwithstanding, instructors are permitted to photocopy isolated articles for noncommercial classroom use without fee. (License No.: 10GA0019/12GB0052/13GB0056/17GB0034/18GB0034)
Download PDF MBE2021-23

Conference Information
Committee MBE NC  
Conference Date 2021-10-28 - 2021-10-29 
Place (in Japanese) (See Japanese page) 
Place (in English) Online 
Topics (in Japanese) (See Japanese page) 
Topics (in English)  
Paper Information
Registration To MBE 
Conference Code 2021-10-MBE-NC 
Language Japanese 
Title (in Japanese) (See Japanese page) 
Sub Title (in Japanese) (See Japanese page) 
Title (in English) Computer simulations of colorectal tumor development 
Sub Title (in English)  
Keyword(1) Circadian ryhthm  
Keyword(2) Cell cycle  
Keyword(3) Intestinal cancer  
Keyword(4) Mathematical model  
1st Author's Name Riku Ichinohe  
1st Author's Affiliation Tohoku University (Tohoku Univ.)
2nd Author's Name Norihiro Katayama  
2nd Author's Affiliation Tohoku University/Shokei Gakuin University (Tohoku Univ./Shokei Univ.)
3rd Author's Name Mitsuyuki Nakao  
3rd Author's Affiliation Tohoku University (Tohoku Univ.)
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Speaker Author-1 
Date Time 2021-10-29 09:40:00 
Presentation Time 25 minutes 
Registration for MBE 
Paper # MBE2021-23 
Volume (vol) vol.121 
Number (no) no.222 
Page pp.32-36 
Date of Issue 2021-10-21 (MBE) 

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