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| Presentation | 2021-10-29 09:40 Computer simulations of colorectal tumor development Riku Ichinohe (Tohoku Univ.), Norihiro Katayama (Tohoku Univ./Shokei Univ.), Mitsuyuki Nakao (Tohoku Univ.)  MBE2021-23 |
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| Abstract | (in Japanese) | (See Japanese page) |
| (in English) | It is known that prevalence of colorectal cancer increases in work schedules that do not follow the circadian rhythm such as shift workers. In this study, we modeled the formation and maintenance mechanism of colonic epithelial tissue that repeats reorganization under the control of the central and peripheral circadian rhythm mechanisms. Based on this, we simulated the dynamics of tumor development by changing intensity of peripheral clock mechanism. Based on the results, we evaluate the carcinogenic risk and link it to proposals for lower-risk lifestyle habits. | |
| Keyword | (in Japanese) | (See Japanese page) |
| (in English) | Circadian ryhthm / Cell cycle / Intestinal cancer / Mathematical model / / / / | |
| Reference Info. | IEICE Tech. Rep., vol. 121, no. 222, MBE2021-23, pp. 32-36, Oct. 2021. | |
| Paper # | MBE2021-23 | |
| Date of Issue | 2021-10-21 (MBE) | |
| ISSN | Online edition: ISSN 2432-6380 | |
| Copyright and reproduction |
All rights are reserved and no part of this publication may be reproduced or transmitted in any form or by any means, electronic or mechanical, including photocopy, recording, or any information storage and retrieval system, without permission in writing from the publisher. Notwithstanding, instructors are permitted to photocopy isolated articles for noncommercial classroom use without fee. (License No.: 10GA0019/12GB0052/13GB0056/17GB0034/18GB0034) | |
| Download PDF | MBE2021-23 |
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| Conference Information | |
| Committee | MBE NC |
| Conference Date | 2021-10-28 - 2021-10-29 |
| Place (in Japanese) | (See Japanese page) |
| Place (in English) | Online |
| Topics (in Japanese) | (See Japanese page) |
| Topics (in English) | |
| Paper Information | |
| Registration To | MBE |
| Conference Code | 2021-10-MBE-NC |
| Language | Japanese |
| Title (in Japanese) | (See Japanese page) |
| Sub Title (in Japanese) | (See Japanese page) |
| Title (in English) | Computer simulations of colorectal tumor development |
| Sub Title (in English) | |
| Keyword(1) | Circadian ryhthm |
| Keyword(2) | Cell cycle |
| Keyword(3) | Intestinal cancer |
| Keyword(4) | Mathematical model |
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| 1st Author's Name | Riku Ichinohe |
| 1st Author's Affiliation | Tohoku University (Tohoku Univ.) |
| 2nd Author's Name | Norihiro Katayama |
| 2nd Author's Affiliation | Tohoku University/Shokei Gakuin University (Tohoku Univ./Shokei Univ.) |
| 3rd Author's Name | Mitsuyuki Nakao |
| 3rd Author's Affiliation | Tohoku University (Tohoku Univ.) |
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| Speaker | Author-1 |
| Date Time | 2021-10-29 09:40:00 |
| Presentation Time | 25 minutes |
| Registration for | MBE |
| Paper # | MBE2021-23 |
| Volume (vol) | vol.121 |
| Number (no) | no.222 |
| Page | pp.32-36 |
| #Pages | 5 |
| Date of Issue | 2021-10-21 (MBE) |
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