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Paper Abstract and Keywords
Presentation 2026-03-06 11:00
Progressive Refinement VMamba Framework and Two-Stage Classification for Nucleus Instance Segmentation
Zeyang Zhang, Seiichiro Kamata (Waseda Univ.) MI2025-96
Abstract (in Japanese) (See Japanese page) 
(in English) Nucleus instance segmentation is essential in computational pathology but remains difficult due to dense nuclei and ambiguous boundaries. This work presents a practical framework that extends the HoVer-Net pipeline with a VMamba-based progressive refinement strategy to enhance local structure modeling and instance separation. A two-stage design further decouples segmentation and classification by applying a ConvNeXt-based classifier to cropped nucleus patches. Experiments on the PanNuke dataset demonstrate consistent improvements over the HoVer-Net baseline in instance-level metrics, including mPQ and bPQ.
Keyword (in Japanese) (See Japanese page) 
(in English) nucleus instance segmentation / histopathology image analysis / progressive refinement / VMamba / two-stage classification / / /  
Reference Info. IEICE Tech. Rep., vol. 125, no. 395, MI2025-96, pp. 135-138, March 2026.
Paper # MI2025-96 
Date of Issue 2026-02-26 (MI) 
ISSN Online edition: ISSN 2432-6380
Copyright
and
reproduction		 All rights are reserved and no part of this publication may be reproduced or transmitted in any form or by any means, electronic or mechanical, including photocopy, recording, or any information storage and retrieval system, without permission in writing from the publisher. Notwithstanding, instructors are permitted to photocopy isolated articles for noncommercial classroom use without fee. (License No.: 10GA0019/12GB0052/13GB0056/17GB0034/18GB0034)
Download PDF MI2025-96

Conference Information
Committee MI  
Conference Date 2026-03-05 - 2026-03-06 
Place (in Japanese) (See Japanese page) 
Place (in English) OKINAWAKEN SEINENKAIKAN 
Topics (in Japanese) (See Japanese page) 
Topics (in English) Medical Imaging, etc. 
Paper Information
Registration To MI 
Conference Code 2026-03-MI 
Language English 
Title (in Japanese) (See Japanese page) 
Sub Title (in Japanese) (See Japanese page) 
Title (in English) Progressive Refinement VMamba Framework and Two-Stage Classification for Nucleus Instance Segmentation 
Sub Title (in English)  
Keyword(1) nucleus instance segmentation  
Keyword(2) histopathology image analysis  
Keyword(3) progressive refinement  
Keyword(4) VMamba  
Keyword(5) two-stage classification  
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1st Author's Name Zeyang Zhang  
1st Author's Affiliation Waseda University (Waseda Univ.)
2nd Author's Name Seiichiro Kamata  
2nd Author's Affiliation Waseda University (Waseda Univ.)
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Speaker Author-1 
Date Time 2026-03-06 11:00:00 
Presentation Time 13 minutes 
Registration for MI 
Paper # MI2025-96 
Volume (vol) vol.125 
Number (no) no.395 
Page pp.135-138 
#Pages 4 
Date of Issue 2026-02-26 (MI) 

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