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Paper Abstract and Keywords
Presentation 2026-03-16 10:30
A Neural-Glial Model of Lateral Habenula Circuits for Cognitive Distortions in Depression
Jingwei Gu (Waseda Univ.), Yoshimasa Tawatsuji (Univ. of Tokyo), Tatsunori Matsui (Waseda Univ.) NC2025-90
Abstract (in Japanese) (See Japanese page) 
(in English) Depression is associated with biased cognition, such as heightened responses to negative events and reduced sensitivity to positive events, which may contribute to symptom persistence. Experimental studies suggest that chronic stress elevates lateral habenula (LHb: lateral habenula) activity and that neuron--astrocyte interactions in LHb are involved in depressive-like behaviors. However, a compact dynamical framework that links these findings to conditions under which circuit activity fails to recover remains limited. We constructed a minimal LHb--locus coeruleus (LC: locus coeruleus) rate model augmented with an astrocytic state variable $Y$ and a coupling modulation $g(Y)$. A brief stress-like rectangular input can shift the system into a sustained high-activity state (High Plateau), and the maximal modulation $g_{max}$ controls a qualitative transition from transient to persistent responses. A two-dimensional parameter sweep further identified the region in which High Plateau occurs. These results provide a basis for interpreting stress--LHb--astrocyte positive feedback as a state switch that becomes difficult to reverse.
Keyword (in Japanese) (See Japanese page) 
(in English) depression / cognitive bias / lateral habenula / locus coeruleus / astrocyte / / /  
Reference Info. IEICE Tech. Rep., vol. 125, no. 413, NC2025-90, pp. 1-5, March 2026.
Paper # NC2025-90 
Date of Issue 2026-03-09 (NC) 
ISSN Online edition: ISSN 2432-6380
Copyright
and
reproduction		 All rights are reserved and no part of this publication may be reproduced or transmitted in any form or by any means, electronic or mechanical, including photocopy, recording, or any information storage and retrieval system, without permission in writing from the publisher. Notwithstanding, instructors are permitted to photocopy isolated articles for noncommercial classroom use without fee. (License No.: 10GA0019/12GB0052/13GB0056/17GB0034/18GB0034)
Download PDF NC2025-90

Conference Information
Committee NC MBE  
Conference Date 2026-03-16 - 2026-03-18 
Place (in Japanese) (See Japanese page) 
Place (in English) The University of Tokyo 
Topics (in Japanese) (See Japanese page) 
Topics (in English) General 
Paper Information
Registration To NC 
Conference Code 2026-03-NC-MBE 
Language Japanese 
Title (in Japanese) (See Japanese page) 
Sub Title (in Japanese) (See Japanese page) 
Title (in English) A Neural-Glial Model of Lateral Habenula Circuits for Cognitive Distortions in Depression 
Sub Title (in English)  
Keyword(1) depression  
Keyword(2) cognitive bias  
Keyword(3) lateral habenula  
Keyword(4) locus coeruleus  
Keyword(5) astrocyte  
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Keyword(8)  
1st Author's Name Jingwei Gu  
1st Author's Affiliation Waseda University (Waseda Univ.)
2nd Author's Name Yoshimasa Tawatsuji  
2nd Author's Affiliation The University of Tokyo (Univ. of Tokyo)
3rd Author's Name Tatsunori Matsui  
3rd Author's Affiliation Waseda University (Waseda Univ.)
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Speaker Author-1 
Date Time 2026-03-16 10:30:00 
Presentation Time 25 minutes 
Registration for NC 
Paper # NC2025-90 
Volume (vol) vol.125 
Number (no) no.413 
Page pp.1-5 
#Pages 5 
Date of Issue 2026-03-09 (NC) 

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