| Paper Abstract and Keywords |
| Presentation |
2006-06-15 13:50
Drug-response prediction from microarray data using network-based de-noising
Tsuyoshi Kato (Univ. of Tokyo), Koh Miura, Yukio Murata (Tohoku Univ.), Kiyoshi Asai (Univ. of Tokyo), Paul B. Horton, Wataru Fujibuchi, Koji Tsuda (AIST) |
| Abstract |
(in Japanese) |
(See Japanese page) |
| (in English) |
Prediction of human cell response to anti-cancer drugs (compounds) from microarray data is a challenging problem, due to the noise properties of microarrays as well as the high variance of living cell responses to drugs. Hence there is a strong need for more practical and robust methods than standard methods for real-value prediction. We devised an extended version of the off-subspace noise-reduction (de-noising) method to incorporate heterogeneous network data such as sequence similarity or protein protein interactions into a single framework. Experimental results show that prediction performance is improved by combining a prediction method with our de-noising method. |
| Keyword |
(in Japanese) |
(See Japanese page) |
| (in English) |
microarray data / anti-cancer drugs / network / off-subspace de-noising method / / / / |
| Reference Info. |
IEICE Tech. Rep., vol. 106, no. 101, NC2006-16, pp. 43-48, June 2006. |
| Paper # |
NC2006-16 |
| Date of Issue |
2006-06-08 (NC) |
| ISSN |
Print edition: ISSN 0913-5685 |
| Download PDF |
|
| Conference Information |
| Committee |
NC |
| Conference Date |
2006-06-15 - 2006-06-16 |
| Place (in Japanese) |
(See Japanese page) |
| Place (in English) |
OIST |
| Topics (in Japanese) |
(See Japanese page) |
| Topics (in English) |
Bio-data Mining with Machine Learning and General |
| Paper Information |
| Registration To |
NC |
| Conference Code |
2006-06-NC |
| Language |
English (Japanese title is available) |
| Title (in Japanese) |
(See Japanese page) |
| Sub Title (in Japanese) |
(See Japanese page) |
| Title (in English) |
Drug-response prediction from microarray data using network-based de-noising |
| Sub Title (in English) |
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| Keyword(1) |
microarray data |
| Keyword(2) |
anti-cancer drugs |
| Keyword(3) |
network |
| Keyword(4) |
off-subspace de-noising method |
| Keyword(5) |
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| Keyword(6) |
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| 1st Author's Name |
Tsuyoshi Kato |
| 1st Author's Affiliation |
University of Tokyo (Univ. of Tokyo) |
| 2nd Author's Name |
Koh Miura |
| 2nd Author's Affiliation |
Tohoku University (Tohoku Univ.) |
| 3rd Author's Name |
Yukio Murata |
| 3rd Author's Affiliation |
Tohoku University (Tohoku Univ.) |
| 4th Author's Name |
Kiyoshi Asai |
| 4th Author's Affiliation |
University of Tokyo (Univ. of Tokyo) |
| 5th Author's Name |
Paul B. Horton |
| 5th Author's Affiliation |
AIST (AIST) |
| 6th Author's Name |
Wataru Fujibuchi |
| 6th Author's Affiliation |
AIST (AIST) |
| 7th Author's Name |
Koji Tsuda |
| 7th Author's Affiliation |
AIST (AIST) |
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| Speaker |
Author-1 |
| Date Time |
2006-06-15 13:50:00 |
| Presentation Time |
20 minutes |
| Registration for |
NC |
| Paper # |
NC2006-16 |
| Volume (vol) |
vol.106 |
| Number (no) |
no.101 |
| Page |
pp.43-48 |
| #Pages |
6 |
| Date of Issue |
2006-06-08 (NC) |