| Paper Abstract and Keywords |
| Presentation |
2007-01-26 16:20
Proposal of technique for handily detecting medicine that causes QT prolongation syndrome
Shigeki Hiramatsu, Toshihiro Nishimura (Waseda Univ.) |
| Abstract |
(in Japanese) |
(See Japanese page) |
| (in English) |
A Technique for Simple Detection of Drug-Induced Long QT Syndrome
Abstract: Non-antiarrhythmic drugs such as antiallergic and antibacterial agents may delay ventricular repolarization, resulting in development of adverse events. The action of such drugs is characterized by a prolonged QT interval on a body surface electrocardiogram (ECG), and these drugs may subsequently induce ventricular arrhythmia (torsades de pointes, TdP), followed by fainting and sudden death. This study was performed to examine a method for simple detection of drug-induced prolonged QT interval by consecutive wavelet analysis in the electrocardiogram of healthy volunteers who were administered a drug that may induce a prolonged QT interval. The results of the study showed that a prolonged QT interval could be detected with time, and that the prolonged QT interval recovered during the measurement period due to homeostasis maintained by autonomic nervous system activity via the chemoreceptor reflex. These results suggest that a drug-induced prolonged QT interval may be inappropriately evaluated when the QT interval is measured at certain intervals. |
| Keyword |
(in Japanese) |
(See Japanese page) |
| (in English) |
drug-induced long QT syndrome / QT interval / wavelet transform / ICH / / / / |
| Reference Info. |
IEICE Tech. Rep., vol. 106, no. 506, MBE2006-113, pp. 69-72, Jan. 2007. |
| Paper # |
MBE2006-113 |
| Date of Issue |
2007-01-19 (MBE) |
| ISSN |
Print edition: ISSN 0913-5685 |
| Download PDF |
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| Conference Information |
| Committee |
MBE |
| Conference Date |
2007-01-26 - 2007-01-26 |
| Place (in Japanese) |
(See Japanese page) |
| Place (in English) |
Kagoshima-Shichoson-Jichi-Kaikan Bldg. |
| Topics (in Japanese) |
(See Japanese page) |
| Topics (in English) |
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| Paper Information |
| Registration To |
MBE |
| Conference Code |
2007-01-MBE |
| Language |
Japanese |
| Title (in Japanese) |
(See Japanese page) |
| Sub Title (in Japanese) |
(See Japanese page) |
| Title (in English) |
Proposal of technique for handily detecting medicine that causes QT prolongation syndrome |
| Sub Title (in English) |
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| Keyword(1) |
drug-induced long QT syndrome |
| Keyword(2) |
QT interval |
| Keyword(3) |
wavelet transform |
| Keyword(4) |
ICH |
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| 1st Author's Name |
Shigeki Hiramatsu |
| 1st Author's Affiliation |
Waseda University Graduate School of Information, Production and Systems (Waseda Univ.) |
| 2nd Author's Name |
Toshihiro Nishimura |
| 2nd Author's Affiliation |
Waseda University Graduate School of Information, Production and Systems (Waseda Univ.) |
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| Speaker |
Author-1 |
| Date Time |
2007-01-26 16:20:00 |
| Presentation Time |
20 minutes |
| Registration for |
MBE |
| Paper # |
MBE2006-113 |
| Volume (vol) |
vol.106 |
| Number (no) |
no.506 |
| Page |
pp.69-72 |
| #Pages |
4 |
| Date of Issue |
2007-01-19 (MBE) |