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| 講演抄録／キーワード | ||
| 講演名 | 2009-01-19 10:30 ［特別招待講演］Molecular Imaging at National Taiwan University ○Pai-Chi Li（National Taiwan Univ.）  MI2008-56 |
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| 抄録 | （和） | Molecular imaging has attracted widespread research attention. It can be generally defined as any measurement of events occurring at the molecular level in a spatially and temporally resolved manner. In other words, it is the characterization and measurements of biological processes in living animals, model systems, and humans at the molecular level using remote imaging detectors. Recent interest in the development of novel strategies for the production of nanoparticles also helps accelerate the development of molecular imaging and it is being pursued in all areas of noninvasive medical imaging, including nuclear medicine, magnetic resonance imaging, ultrasound and optics. Each imaging modality has unique advantages and disadvantages, and ultimately the best approach is dependent upon the question being addressed. It is important to note that one major premise of molecular imaging is that it is not defined by the imaging technologies that underpin acquisition of the final image, but rather is driven by the underlying biological questions. In this talk, we will overview the research activities of molecular imaging at National Taiwan University. In addition to a general introduction, recent development of ultrasonic molecular imaging and photoacoustic molecular imaging will also be specifically described. Ultrasonic imaging and photoacoustic imaging provide unique advantages and also face specific challenges. Ultrasonic molecular imaging, on one hand, is based on mechanical properties of the image object and many unique applications have been developed. With the aid of superior spatial resolution, high frequency ultrasound imaging has also evolved from clinical anatomical imaging to probing of molecular processes on small animals for pre-clinical research. Photoacoustic imaging, on the other hand, combines advantages of both optics and acoustics. Research developments in imaging physics and instrumentation have also found promising biomedical applications. In addition, microbubbles typically used in ultrasonic imaging as the contrast agent present unique mechanical properties and the associated acoustic cavitation has been exploited for therapeutic purposes. Similarly, gold nanoparticles are found to be an ideal contrast agent for photoacoustic imaging for its bioconjugation capabilities and presumed safety. The efficient light absorption of gold nanoparticles and abilities to tune their optical properties have also led to new photothermal therapy techniques. We will review our efforts in physics, instrumentation and applications of ultrasonic and photoacoustic imaging. New development in combined diagnosis with therapy for both modalities will also be introduced, with a discussion on possible synergy and the technical difficulties that each modality faces, before critical clinical impact can be made. |
| （英） | Molecular imaging has attracted widespread research attention. It can be generally defined as any measurement of events occurring at the molecular level in a spatially and temporally resolved manner. In other words, it is the characterization and measurements of biological processes in living animals, model systems, and humans at the molecular level using remote imaging detectors. Recent interest in the development of novel strategies for the production of nanoparticles also helps accelerate the development of molecular imaging and it is being pursued in all areas of noninvasive medical imaging, including nuclear medicine, magnetic resonance imaging, ultrasound and optics. Each imaging modality has unique advantages and disadvantages, and ultimately the best approach is dependent upon the question being addressed. It is important to note that one major premise of molecular imaging is that it is not defined by the imaging technologies that underpin acquisition of the final image, but rather is driven by the underlying biological questions. In this talk, we will overview the research activities of molecular imaging at National Taiwan University. In addition to a general introduction, recent development of ultrasonic molecular imaging and photoacoustic molecular imaging will also be specifically described. Ultrasonic imaging and photoacoustic imaging provide unique advantages and also face specific challenges. Ultrasonic molecular imaging, on one hand, is based on mechanical properties of the image object and many unique applications have been developed. With the aid of superior spatial resolution, high frequency ultrasound imaging has also evolved from clinical anatomical imaging to probing of molecular processes on small animals for pre-clinical research. Photoacoustic imaging, on the other hand, combines advantages of both optics and acoustics. Research developments in imaging physics and instrumentation have also found promising biomedical applications. In addition, microbubbles typically used in ultrasonic imaging as the contrast agent present unique mechanical properties and the associated acoustic cavitation has been exploited for therapeutic purposes. Similarly, gold nanoparticles are found to be an ideal contrast agent for photoacoustic imaging for its bioconjugation capabilities and presumed safety. The efficient light absorption of gold nanoparticles and abilities to tune their optical properties have also led to new photothermal therapy techniques. We will review our efforts in physics, instrumentation and applications of ultrasonic and photoacoustic imaging. New development in combined diagnosis with therapy for both modalities will also be introduced, with a discussion on possible synergy and the technical difficulties that each modality faces, before critical clinical impact can be made. |
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| キーワード | （和） | molecular imaging / National Taiwan University / ultrasonic imaging / photoacoustic imaging / / / / |
| （英） | molecular imaging / National Taiwan University / ultrasonic imaging / photoacoustic imaging / / / / | |
| 文献情報 | 信学技報, vol. 108, no. 385, MI2008-56, pp. 3-3, 2009年1月. | |
| 資料番号 | MI2008-56 | |
| 発行日 | 2009-01-12 (MI) | |
| ISSN | Print edition: ISSN 0913-5685 Online edition: ISSN 2432-6380 | |
| 著作権に ついて |
技術研究報告に掲載された論文の著作権は電子情報通信学会に帰属します．(許諾番号：10GA0019/12GB0052/13GB0056/17GB0034/18GB0034) | |
| PDFダウンロード | MI2008-56 |
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| 研究会情報 | |
| 研究会 | MI |
| 開催期間 | 2009-01-19 - 2009-01-21 |
| 開催地（和） | 国立台湾大学(台北市) |
| 開催地（英） | National Taiwan University |
| テーマ（和） | 医用画像一般 |
| テーマ（英） | Medical Imaging |
| 講演論文情報の詳細 | |
| 申込み研究会 | MI |
| 会議コード | 2009-01-MI |
| 本文の言語 | 英語 |
| タイトル（和） | |
| サブタイトル（和） | |
| タイトル（英） | Molecular Imaging at National Taiwan University |
| サブタイトル（英） | |
| キーワード(1)（和/英） | molecular imaging / molecular imaging |
| キーワード(2)（和/英） | National Taiwan University / National Taiwan University |
| キーワード(3)（和/英） | ultrasonic imaging / ultrasonic imaging |
| キーワード(4)（和/英） | photoacoustic imaging / photoacoustic imaging |
| キーワード(5)（和/英） | / |
| キーワード(6)（和/英） | / |
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| 第1著者 氏名（和/英/ヨミ） | Pai-Chi Li / Pai-Chi Li / |
| 第1著者 所属（和/英） | National Taiwan University (略称： National Taiwan Univ.) National Taiwan University (略称： National Taiwan Univ.) |
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| 講演者 | 第1著者 |
| 発表日時 | 2009-01-19 10:30:00 |
| 発表時間 | 20分 |
| 申込先研究会 | MI |
| 資料番号 | MI2008-56 |
| 巻番号（vol） | vol.108 |
| 号番号（no） | no.385 |
| ページ範囲 | p.3 |
| ページ数 | 1 |
| 発行日 | 2009-01-12 (MI) |
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