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| 講演名 | 2010-01-28 14:00 ［特別招待講演］Techniques and Applications of Multi-modality Small Animal Imaging in Cancer Research ○Ai-Ho Liao・Pai-Chi LI（National Taiwan Univ.）  MI2009-111 |
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| 抄録 | （和） | Small-animal models are extensively used in disease research, genomics studies, drug development, and developmental biology. The development of noninvasive small-animal imaging techniques with adequate spatial resolution and sensitivity is of prime importance. In particular, multimodality small-animal imaging can provide complementary information that single modality cannot offfer. This paper presents the role of high frequency ultrasound (microUS) in multimodality small animal imaging for cancer research and progress for microUS and small-animal positron-emission tomography (microPET) multimodality small animal imaging. The following demonstrations are included. First, registration of microUS/microPET is performed using a three-dimensional registration method. In addition, microUS was combined with microPET for tumor progressive assessment. MicroUS provides anatomical information which can be used for tumor volume measurements while microPET is a functional imaging method with positron-emitting radiophamaceuticals, such as 18F-labeled deoxyglucose, [18F]FDG. To investigate the feasibility of the functional information provided from microUS, contrast enhanced ultrasound (CEUS) technique is an alternative way to characterize three vascular contrast phases of liver focal lesions in small animal. Finally, the multimodality N-succinimidyl-4-[18F]fluorobenzoate labeled tumor angiogenesis-related vascular endothelial growth factor receptor 2 targeted microbubbles (tMBs) were synthesized and the biologic characteristics of the tMBs in human breast-cancer-bearing mice were investigated with microPET and microUS. |
| （英） | Small-animal models are extensively used in disease research, genomics studies, drug development, and developmental biology. The development of noninvasive small-animal imaging techniques with adequate spatial resolution and sensitivity is of prime importance. In particular, multimodality small-animal imaging can provide complementary information that single modality cannot offfer. This paper presents the role of high frequency ultrasound (microUS) in multimodality small animal imaging for cancer research and progress for microUS and small-animal positron-emission tomography (microPET) multimodality small animal imaging. The following demonstrations are included. First, registration of microUS/microPET is performed using a three-dimensional registration method. In addition, microUS was combined with microPET for tumor progressive assessment. MicroUS provides anatomical information which can be used for tumor volume measurements while microPET is a functional imaging method with positron-emitting radiophamaceuticals, such as 18F-labeled deoxyglucose, [18F]FDG. To investigate the feasibility of the functional information provided from microUS, contrast enhanced ultrasound (CEUS) technique is an alternative way to characterize three vascular contrast phases of liver focal lesions in small animal. Finally, the multimodality N-succinimidyl-4-[18F]fluorobenzoate labeled tumor angiogenesis-related vascular endothelial growth factor receptor 2 targeted microbubbles (tMBs) were synthesized and the biologic characteristics of the tMBs in human breast-cancer-bearing mice were investigated with microPET and microUS. | |
| キーワード | （和） | microUS / microPET / multimodality imaging / molecular imaging / / / / |
| （英） | microUS / microPET / multimodality imaging / molecular imaging / / / / | |
| 文献情報 | 信学技報, vol. 109, no. 407, MI2009-111, pp. 195-200, 2010年1月. | |
| 資料番号 | MI2009-111 | |
| 発行日 | 2010-01-21 (MI) | |
| ISSN | Print edition: ISSN 0913-5685 Online edition: ISSN 2432-6380 | |
| 著作権に ついて |
技術研究報告に掲載された論文の著作権は電子情報通信学会に帰属します．(許諾番号：10GA0019/12GB0052/13GB0056/17GB0034/18GB0034) | |
| PDFダウンロード | MI2009-111 |
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| 研究会情報 | |
| 研究会 | MI |
| 開催期間 | 2010-01-28 - 2010-01-29 |
| 開催地（和） | 那覇市ぶんかテンブス館 |
| 開催地（英） | Naha-Bunka-Tenbusu |
| テーマ（和） | 医用画像一般 |
| テーマ（英） | Medical Imaging |
| 講演論文情報の詳細 | |
| 申込み研究会 | MI |
| 会議コード | 2010-01-MI |
| 本文の言語 | 英語 |
| タイトル（和） | |
| サブタイトル（和） | |
| タイトル（英） | Techniques and Applications of Multi-modality Small Animal Imaging in Cancer Research |
| サブタイトル（英） | |
| キーワード(1)（和/英） | microUS / microUS |
| キーワード(2)（和/英） | microPET / microPET |
| キーワード(3)（和/英） | multimodality imaging / multimodality imaging |
| キーワード(4)（和/英） | molecular imaging / molecular imaging |
| キーワード(5)（和/英） | / |
| キーワード(6)（和/英） | / |
| キーワード(7)（和/英） | / |
| キーワード(8)（和/英） | / |
| 第1著者 氏名（和/英/ヨミ） | Ai-Ho Liao / Ai-Ho Liao / |
| 第1著者 所属（和/英） | National Taiwan University (略称： National Taiwan Univ.) National Taiwan University (略称： National Taiwan Univ.) |
| 第2著者 氏名（和/英/ヨミ） | Pai-Chi LI / Pai-Chi LI / |
| 第2著者 所属（和/英） | National Taiwan University (略称： National Taiwan Univ.) National Taiwan University (略称： National Taiwan Univ.) |
| 講演者 | 第1著者 |
| 発表日時 | 2010-01-28 14:00:00 |
| 発表時間 | 40分 |
| 申込先研究会 | MI |
| 資料番号 | MI2009-111 |
| 巻番号（vol） | vol.109 |
| 号番号（no） | no.407 |
| ページ範囲 | pp.195-200 |
| ページ数 | 6 |
| 発行日 | 2010-01-21 (MI) |
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