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Paper Abstract and Keywords
Presentation 2010-01-28 14:00
[Special Invited Talk] Techniques and Applications of Multi-modality Small Animal Imaging in Cancer Research
Ai-Ho Liao, Pai-Chi LI (National Taiwan Univ.) MI2009-111
Abstract (in Japanese) (See Japanese page) 
(in English) Small-animal models are extensively used in disease research, genomics studies, drug development, and developmental biology. The development of noninvasive small-animal imaging techniques with adequate spatial resolution and sensitivity is of prime importance. In particular, multimodality small-animal imaging can provide complementary information that single modality cannot offfer. This paper presents the role of high frequency ultrasound (microUS) in multimodality small animal imaging for cancer research and progress for microUS and small-animal positron-emission tomography (microPET) multimodality small animal imaging. The following demonstrations are included. First, registration of microUS/microPET is performed using a three-dimensional registration method. In addition, microUS was combined with microPET for tumor progressive assessment. MicroUS provides anatomical information which can be used for tumor volume measurements while microPET is a functional imaging method with positron-emitting radiophamaceuticals, such as 18F-labeled deoxyglucose, [18F]FDG. To investigate the feasibility of the functional information provided from microUS, contrast enhanced ultrasound (CEUS) technique is an alternative way to characterize three vascular contrast phases of liver focal lesions in small animal. Finally, the multimodality N-succinimidyl-4-[18F]fluorobenzoate labeled tumor angiogenesis-related vascular endothelial growth factor receptor 2 targeted microbubbles (tMBs) were synthesized and the biologic characteristics of the tMBs in human breast-cancer-bearing mice were investigated with microPET and microUS.
Keyword (in Japanese) (See Japanese page) 
(in English) microUS / microPET / multimodality imaging / molecular imaging / / / /  
Reference Info. IEICE Tech. Rep., vol. 109, no. 407, MI2009-111, pp. 195-200, Jan. 2010.
Paper # MI2009-111 
Date of Issue 2010-01-21 (MI) 
ISSN Print edition: ISSN 0913-5685    Online edition: ISSN 2432-6380
Copyright
and
reproduction		 All rights are reserved and no part of this publication may be reproduced or transmitted in any form or by any means, electronic or mechanical, including photocopy, recording, or any information storage and retrieval system, without permission in writing from the publisher. Notwithstanding, instructors are permitted to photocopy isolated articles for noncommercial classroom use without fee. (License No.: 10GA0019/12GB0052/13GB0056/17GB0034/18GB0034)
Download PDF MI2009-111

Conference Information
Committee MI  
Conference Date 2010-01-28 - 2010-01-29 
Place (in Japanese) (See Japanese page) 
Place (in English) Naha-Bunka-Tenbusu 
Topics (in Japanese) (See Japanese page) 
Topics (in English) Medical Imaging 
Paper Information
Registration To MI 
Conference Code 2010-01-MI 
Language English 
Title (in Japanese) (See Japanese page) 
Sub Title (in Japanese) (See Japanese page) 
Title (in English) Techniques and Applications of Multi-modality Small Animal Imaging in Cancer Research 
Sub Title (in English)  
Keyword(1) microUS  
Keyword(2) microPET  
Keyword(3) multimodality imaging  
Keyword(4) molecular imaging  
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1st Author's Name Ai-Ho Liao  
1st Author's Affiliation National Taiwan University (National Taiwan Univ.)
2nd Author's Name Pai-Chi LI  
2nd Author's Affiliation National Taiwan University (National Taiwan Univ.)
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Speaker Author-1 
Date Time 2010-01-28 14:00:00 
Presentation Time 40 minutes 
Registration for MI 
Paper # MI2009-111 
Volume (vol) vol.109 
Number (no) no.407 
Page pp.195-200 
#Pages 6 
Date of Issue 2010-01-21 (MI) 

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