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Paper Abstract and Keywords
Presentation 2010-03-10 10:40
A Study on Path Following of Label-Permuted Solution for Support Vector Machine and its Application for Microarray Data Analysis
Yuta Ishikawa, Kouta Isobe, Ichiro Takeuchi (Nagoya Inst. of Tech.) NC2009-132
Abstract (in Japanese) (See Japanese page) 
(in English) Microarray technology enables us to measure expression levels of thousands of genes simultaneously.The fundamental task of microarray data analysis is to find differentially expressed genes between two samples. In
this study we consider how to find differentially expressed gene sets rather than individual genes) between two samples. This task is called gene set analysis and it is mathematically formulated as multivariate two-sample test. As an approach of gene set analysis, we introduce a multivariate two-sample test whose test statistic is given by the classification error of support vector machine (SVM) classifier. The null distribution of the statistic is computed based on label permutation operation, and thus we need to train many SVM classifiers for permuted labels. In this paper we are concerned with the problem of reducing the computational cost of this operation by proposing a path-following algorithm to compute the path of label-permuted SVM classifiers.
Keyword (in Japanese) (See Japanese page) 
(in English) Support Vector Machine / Path Following / Label-Permutation / Microarray / GSEA / / /  
Reference Info. IEICE Tech. Rep., vol. 109, no. 461, NC2009-132, pp. 261-266, March 2010.
Paper # NC2009-132 
Date of Issue 2010-03-02 (NC) 
ISSN Print edition: ISSN 0913-5685    Online edition: ISSN 2432-6380
All rights are reserved and no part of this publication may be reproduced or transmitted in any form or by any means, electronic or mechanical, including photocopy, recording, or any information storage and retrieval system, without permission in writing from the publisher. Notwithstanding, instructors are permitted to photocopy isolated articles for noncommercial classroom use without fee. (License No.: 10GA0019/12GB0052/13GB0056/17GB0034/18GB0034)
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Conference Information
Committee NC MBE  
Conference Date 2010-03-09 - 2010-03-11 
Place (in Japanese) (See Japanese page) 
Place (in English) Tamagawa University 
Topics (in Japanese) (See Japanese page) 
Topics (in English) General 
Paper Information
Registration To NC 
Conference Code 2010-03-NC-MBE 
Language Japanese 
Title (in Japanese) (See Japanese page) 
Sub Title (in Japanese) (See Japanese page) 
Title (in English) A Study on Path Following of Label-Permuted Solution for Support Vector Machine and its Application for Microarray Data Analysis 
Sub Title (in English)  
Keyword(1) Support Vector Machine  
Keyword(2) Path Following  
Keyword(3) Label-Permutation  
Keyword(4) Microarray  
Keyword(5) GSEA  
1st Author's Name Yuta Ishikawa  
1st Author's Affiliation Nagoya Institute of Technology (Nagoya Inst. of Tech.)
2nd Author's Name Kouta Isobe  
2nd Author's Affiliation Nagoya Institute of Technology (Nagoya Inst. of Tech.)
3rd Author's Name Ichiro Takeuchi  
3rd Author's Affiliation Nagoya Institute of Technology (Nagoya Inst. of Tech.)
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Speaker Author-1 
Date Time 2010-03-10 10:40:00 
Presentation Time 25 minutes 
Registration for NC 
Paper # NC2009-132 
Volume (vol) vol.109 
Number (no) no.461 
Page pp.261-266 
Date of Issue 2010-03-02 (NC) 

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