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Paper Abstract and Keywords
Presentation 2011-01-27 11:00
Slow-inactivation of voltage-gated Na+ current and spike firing in rat retinal neurons
Sho Harabe, Tamami Motomura, Yuki Hayashida, Nobuki Murayama (Kumamoto Univ) MBE2010-80
Abstract (in Japanese) (See Japanese page) 
(in English) Ganglion cells located at the output of vertebrate retina encode the computational results of the neural circuit into electrical spike trains, to send the information to the brain. Recent studies have shown that voltage-gated Na+ channels, which are responsible for the spike generation, exhibit inactivation with the time constants in the range between a few milliseconds and several hundred milliseconds, thereby contributing to the adaptive output of spikes. However, the slower inactivation in the time scale over seconds has not been previously analyzed in the physiological experiment. In this study, therefore, we made analyses on the transition process of the slow-inactivation of voltage-gated Na^+ current in the ganglion cells acutely dissociated
from rat retinas, by means of voltage-clamp experiments with perforated-patch whole-cell mode. The results indicated that there exist the transition processes of entry into, and recovery from, inactivation with the time constants of several seconds as well as a few milliseconds. Voltage measurements under current-clamp showed that the threshold for action potential firing can be affected by the change of Na^+ current due to the inactivation. The multiple time scales of Na^+ channel inactivation are thought to contribute to history-dependent spike firings in retinal ganglion cells.
Keyword (in Japanese) (See Japanese page) 
(in English) Retinal neuron / History-dependent / Na^+ channel / Inactivation / Action potential firing / / /  
Reference Info. IEICE Tech. Rep., vol. 110, no. 399, MBE2010-80, pp. 9-12, Jan. 2011.
Paper # MBE2010-80 
Date of Issue 2011-01-20 (MBE) 
ISSN Print edition: ISSN 0913-5685    Online edition: ISSN 2432-6380
All rights are reserved and no part of this publication may be reproduced or transmitted in any form or by any means, electronic or mechanical, including photocopy, recording, or any information storage and retrieval system, without permission in writing from the publisher. Notwithstanding, instructors are permitted to photocopy isolated articles for noncommercial classroom use without fee. (License No.: 10GA0019/12GB0052/13GB0056/17GB0034/18GB0034)
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Conference Information
Committee MBE  
Conference Date 2011-01-27 - 2011-01-28 
Place (in Japanese) (See Japanese page) 
Place (in English) Kagoshima University 
Topics (in Japanese) (See Japanese page) 
Topics (in English) ME in general 
Paper Information
Registration To MBE 
Conference Code 2011-01-MBE 
Language Japanese 
Title (in Japanese) (See Japanese page) 
Sub Title (in Japanese) (See Japanese page) 
Title (in English) Slow-inactivation of voltage-gated Na+ current and spike firing in rat retinal neurons 
Sub Title (in English)  
Keyword(1) Retinal neuron  
Keyword(2) History-dependent  
Keyword(3) Na^+ channel  
Keyword(4) Inactivation  
Keyword(5) Action potential firing  
1st Author's Name Sho Harabe  
1st Author's Affiliation Kumamoto University (Kumamoto Univ)
2nd Author's Name Tamami Motomura  
2nd Author's Affiliation Kumamoto University (Kumamoto Univ)
3rd Author's Name Yuki Hayashida  
3rd Author's Affiliation Kumamoto University (Kumamoto Univ)
4th Author's Name Nobuki Murayama  
4th Author's Affiliation Kumamoto University (Kumamoto Univ)
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Speaker Author-1 
Date Time 2011-01-27 11:00:00 
Presentation Time 25 minutes 
Registration for MBE 
Paper # MBE2010-80 
Volume (vol) vol.110 
Number (no) no.399 
Page pp.9-12 
Date of Issue 2011-01-20 (MBE) 

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