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Paper Abstract and Keywords
Presentation 2012-01-20 10:20
Development of automated method for extraction of hippocampal regions computer aided diagnosis for dementia of Alzheimer type
Sho Araki, Hidetaka Arimura (Kyushu Univ.), Takashi Yoshiura (Kyushu Univ. Hospital), Chiaki Tokunaga, Yasuo Yamashita (Kyushu Univ.), Hiroshi Honda (Kyushu Univ. Hospital), Hideki Hirata, Fukai Toyofuku, Masafumi Ohki (Kyushu Univ.) MI2011-120
Abstract (in Japanese) (See Japanese page) 
(in English) Although image features of hippocampal regions including their volumes and shapes would be feasible for diagnosing the dementia of Alzheimer type (DAT) in early stages, it would be very difficult to quantify such features and would be time-consuming to diagnose the DAT. We have attempted to develop an automated segmentation method for three-dimensional (3D) hippocampal regions in magnetic resonance (MR) images. First, hippocampal probabilistic atlases were produced by registering all images of 9 control subjects, which include hippocampal regions determined by a manual method, to a reference image of a subject by using a linear registration followed by a non-linear registration. Next, pixel value probability distributions of the hippocampal regions and their surroundings were obtained from the corresponding regions in all training cases. Finally, hippocampal region of each case was estimated based on a maximum a posteriori estimation using the probabilistic atlas and the pixel value probability distributions of the hippocampal regions and their surroundings. For evaluation of the proposed method, we applied it to ten training cases, and then calculated a Dice similarity coefficient (DSC), which was the degree of the agreement between the hippocampal regions determined by the manual method and the proposed method. The average DSC was 0.63±0.13.
Keyword (in Japanese) (See Japanese page) 
(in English) Dementia of Alzheimer type / Magnetic resonance image / Computer aided diagnosis system / Hippocampus / Maximuma posteriori estimation / / /  
Reference Info. IEICE Tech. Rep., vol. 111, no. 389, MI2011-120, pp. 235-238, Jan. 2012.
Paper # MI2011-120 
Date of Issue 2012-01-12 (MI) 
ISSN Print edition: ISSN 0913-5685    Online edition: ISSN 2432-6380
Copyright
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reproduction		 All rights are reserved and no part of this publication may be reproduced or transmitted in any form or by any means, electronic or mechanical, including photocopy, recording, or any information storage and retrieval system, without permission in writing from the publisher. Notwithstanding, instructors are permitted to photocopy isolated articles for noncommercial classroom use without fee. (License No.: 10GA0019/12GB0052/13GB0056/17GB0034/18GB0034)
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Conference Information
Committee MI  
Conference Date 2012-01-19 - 2012-01-20 
Place (in Japanese) (See Japanese page) 
Place (in English)  
Topics (in Japanese) (See Japanese page) 
Topics (in English)  
Paper Information
Registration To MI 
Conference Code 2012-01-MI 
Language Japanese 
Title (in Japanese) (See Japanese page) 
Sub Title (in Japanese) (See Japanese page) 
Title (in English) Development of automated method for extraction of hippocampal regions computer aided diagnosis for dementia of Alzheimer type 
Sub Title (in English)  
Keyword(1) Dementia of Alzheimer type  
Keyword(2) Magnetic resonance image  
Keyword(3) Computer aided diagnosis system  
Keyword(4) Hippocampus  
Keyword(5) Maximuma posteriori estimation  
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1st Author's Name Sho Araki  
1st Author's Affiliation Kyushu Uinversity (Kyushu Univ.)
2nd Author's Name Hidetaka Arimura  
2nd Author's Affiliation Kyushu Uinversity (Kyushu Univ.)
3rd Author's Name Takashi Yoshiura  
3rd Author's Affiliation Kyushu Uinversity Hospital (Kyushu Univ. Hospital)
4th Author's Name Chiaki Tokunaga  
4th Author's Affiliation Kyushu Uinversity (Kyushu Univ.)
5th Author's Name Yasuo Yamashita  
5th Author's Affiliation Kyushu Uinversity (Kyushu Univ.)
6th Author's Name Hiroshi Honda  
6th Author's Affiliation Kyushu Uinversity Hospital (Kyushu Univ. Hospital)
7th Author's Name Hideki Hirata  
7th Author's Affiliation Kyushu Uinversity (Kyushu Univ.)
8th Author's Name Fukai Toyofuku  
8th Author's Affiliation Kyushu Uinversity (Kyushu Univ.)
9th Author's Name Masafumi Ohki  
9th Author's Affiliation Kyushu Uinversity (Kyushu Univ.)
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Speaker Author-1 
Date Time 2012-01-20 10:20:00 
Presentation Time 15 minutes 
Registration for MI 
Paper # MI2011-120 
Volume (vol) vol.111 
Number (no) no.389 
Page pp.235-238 
#Pages 4 
Date of Issue 2012-01-12 (MI) 

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