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| Presentation | 2017-11-25 10:00 Basic study of animal test alternative using cultured nerve cell for the safety assessment of neural interface Yurina Yoshimura, Hiroyuki Tashiro, Yuzo Kayamori (kyushu Univ.)  MBE2017-49 |
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| Abstract | (in Japanese) | (See Japanese page) |
| (in English) | Direct neural interface is intensively developed to artificially reproduce a lost sensation. The safety of it is evaluated by animal experiment. However, the evaluation using experimental animal has not only problems of high economic and temporal cost but also ethical issues. Therefore, we are developing an animal test alternative that can evaluate the influence of stimulation to nerve cells in vitro. In this study, we investigated the period during which neural activity of nerve cells (NG108–15) cultured on multi electrode array is maintained. Using culture method with medium circulation, the spontaneous-spike activity was able to be obtained until 62.5 hours. Furthermore, the record of nerve activity over 9 days was achieved by culture method with medium exchanging. | |
| Keyword | (in Japanese) | (See Japanese page) |
| (in English) | Multi electrode array / NG108-15 cells / Spontaneous spike activity / Direct neural interface / Animal test alternative / / / | |
| Reference Info. | IEICE Tech. Rep., vol. 117, no. 324, MBE2017-49, pp. 13-16, Nov. 2017. | |
| Paper # | MBE2017-49 | |
| Date of Issue | 2017-11-17 (MBE) | |
| ISSN | Print edition: ISSN 0913-5685 Online edition: ISSN 2432-6380 | |
| Copyright and reproduction |
All rights are reserved and no part of this publication may be reproduced or transmitted in any form or by any means, electronic or mechanical, including photocopy, recording, or any information storage and retrieval system, without permission in writing from the publisher. Notwithstanding, instructors are permitted to photocopy isolated articles for noncommercial classroom use without fee. (License No.: 10GA0019/12GB0052/13GB0056/17GB0034/18GB0034) | |
| Download PDF | MBE2017-49 |
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| Conference Information | |
| Committee | MBE NC |
| Conference Date | 2017-11-24 - 2017-11-25 |
| Place (in Japanese) | (See Japanese page) |
| Place (in English) | Tohoku University |
| Topics (in Japanese) | (See Japanese page) |
| Topics (in English) | BCI/BMI, generall |
| Paper Information | |
| Registration To | MBE |
| Conference Code | 2017-11-MBE-NC |
| Language | Japanese |
| Title (in Japanese) | (See Japanese page) |
| Sub Title (in Japanese) | (See Japanese page) |
| Title (in English) | Basic study of animal test alternative using cultured nerve cell for the safety assessment of neural interface |
| Sub Title (in English) | |
| Keyword(1) | Multi electrode array |
| Keyword(2) | NG108-15 cells |
| Keyword(3) | Spontaneous spike activity |
| Keyword(4) | Direct neural interface |
| Keyword(5) | Animal test alternative |
| Keyword(6) | |
| Keyword(7) | |
| Keyword(8) | |
| 1st Author's Name | Yurina Yoshimura |
| 1st Author's Affiliation | Kyushu University (kyushu Univ.) |
| 2nd Author's Name | Hiroyuki Tashiro |
| 2nd Author's Affiliation | Kyushu University (kyushu Univ.) |
| 3rd Author's Name | Yuzo Kayamori |
| 3rd Author's Affiliation | Kyushu University (kyushu Univ.) |
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| Speaker | Author-1 |
| Date Time | 2017-11-25 10:00:00 |
| Presentation Time | 25 minutes |
| Registration for | MBE |
| Paper # | MBE2017-49 |
| Volume (vol) | vol.117 |
| Number (no) | no.324 |
| Page | pp.13-16 |
| #Pages | 4 |
| Date of Issue | 2017-11-17 (MBE) |
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