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Paper Abstract and Keywords
Presentation 2019-03-01 11:30
Quantitative assessment of drug side effect on hERG channels based on artificial bilayer lipid membranes and cell-free expression system
Ryo yokota, Miki Kato, Daichi Yamaura, Yusuke Tsuneta, Madoka Sato, Daisuke Tadaki, Maki Komiya, Hideaki Yamamoto (Tohoku Univ.), Haruka Inoue, Yuzuru Tozawa (Saitama Univ.), Michio Niwano (Tohoku Fukushi Univ.), Ayumi Hirano-Iwata (Tohoku Univ.) CPM2018-119
Abstract (in Japanese) (See Japanese page) 
(in English) We aim to develop a drug screening system based on a reconstitution system, in which an ion channel is embedded in an artificial bilayer lipid membrane. We have reported the formation of a stable lipid bilayer membrane (BLM) based on silicon (Si) microfabrication and the method for promotion of embedding ion channels in the membranes. Here, we applied the BLM system to quantitative assessment of drug side effects on cell-free synthesized hERG channel proteins.
Keyword (in Japanese) (See Japanese page) 
(in English) Semiconductor microfabrication / Ion channel / Lipid bilayer membrane / Cell-free expression system / Drug side effect / / /  
Reference Info. IEICE Tech. Rep., vol. 118, no. 461, CPM2018-119, pp. 75-76, Feb. 2019.
Paper # CPM2018-119 
Date of Issue 2019-02-21 (CPM) 
ISSN Print edition: ISSN 0913-5685    Online edition: ISSN 2432-6380
Copyright
and
reproduction		 All rights are reserved and no part of this publication may be reproduced or transmitted in any form or by any means, electronic or mechanical, including photocopy, recording, or any information storage and retrieval system, without permission in writing from the publisher. Notwithstanding, instructors are permitted to photocopy isolated articles for noncommercial classroom use without fee. (License No.: 10GA0019/12GB0052/13GB0056/17GB0034/18GB0034)
Download PDF CPM2018-119

Conference Information
Committee CPM  
Conference Date 2019-02-28 - 2019-03-01 
Place (in Japanese) (See Japanese page) 
Place (in English)  
Topics (in Japanese) (See Japanese page) 
Topics (in English) Young Researcher's Conference 
Paper Information
Registration To CPM 
Conference Code 2019-02-CPM 
Language Japanese 
Title (in Japanese) (See Japanese page) 
Sub Title (in Japanese) (See Japanese page) 
Title (in English) Quantitative assessment of drug side effect on hERG channels based on artificial bilayer lipid membranes and cell-free expression system 
Sub Title (in English)  
Keyword(1) Semiconductor microfabrication  
Keyword(2) Ion channel  
Keyword(3) Lipid bilayer membrane  
Keyword(4) Cell-free expression system  
Keyword(5) Drug side effect  
Keyword(6)  
Keyword(7)  
Keyword(8)  
1st Author's Name Ryo yokota  
1st Author's Affiliation Tohoku University (Tohoku Univ.)
2nd Author's Name Miki Kato  
2nd Author's Affiliation Tohoku University (Tohoku Univ.)
3rd Author's Name Daichi Yamaura  
3rd Author's Affiliation Tohoku University (Tohoku Univ.)
4th Author's Name Yusuke Tsuneta  
4th Author's Affiliation Tohoku University (Tohoku Univ.)
5th Author's Name Madoka Sato  
5th Author's Affiliation Tohoku University (Tohoku Univ.)
6th Author's Name Daisuke Tadaki  
6th Author's Affiliation Tohoku University (Tohoku Univ.)
7th Author's Name Maki Komiya  
7th Author's Affiliation Tohoku University (Tohoku Univ.)
8th Author's Name Hideaki Yamamoto  
8th Author's Affiliation Tohoku University (Tohoku Univ.)
9th Author's Name Haruka Inoue  
9th Author's Affiliation Saitama University (Saitama Univ.)
10th Author's Name Yuzuru Tozawa  
10th Author's Affiliation Saitama University (Saitama Univ.)
11th Author's Name Michio Niwano  
11th Author's Affiliation Tohoku Fukushi University (Tohoku Fukushi Univ.)
12th Author's Name Ayumi Hirano-Iwata  
12th Author's Affiliation Tohoku University (Tohoku Univ.)
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Speaker Author-1 
Date Time 2019-03-01 11:30:00 
Presentation Time 15 minutes 
Registration for CPM 
Paper # CPM2018-119 
Volume (vol) vol.118 
Number (no) no.461 
Page pp.75-76 
#Pages 2 
Date of Issue 2019-02-21 (CPM) 

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