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Paper Abstract and Keywords
Presentation 2020-01-30 10:00
Construction of Basis Vectors for Representation of Immunostaining Combination by Non-negative Matrix Decomposition
Kaho Ko, Noriaki Hashimoto, Tatsuya Yokota (NITech), Masato Nakaguro, Kei Kohno, Shigeo Nakamura (NUH), Ichiro Takeuchi, Hidekata Hontani (NITech) MI2019-99
Abstract (in Japanese) (See Japanese page) 
(in English) In this paper, we propose a method that constructs a set of basis vectors for representing combination of immunostaining used to diagnose malignant lymphoma with fewer parameters by means of constrained non-negative matrix factorization. Immunostaining combinations can be represented by binary matrices, of which operations are Boolean, and it is known that matrix decomposition with Boolean operation is NP-hard. We hence relax this problem to a constrained non-negative real matrix decomposition and solve the relaxed problem using an ADMM (Alternating Direction Method of Multipliers). In addition, we introduce an L1-regularization technique to make the method stable against stains infrequently used. We show the concrete algorithms and demonstrate the experimental results that show the performance of the proposed method.
Keyword (in Japanese) (See Japanese page) 
(in English) Non-negative matrix decomposition / Boolean Matrix Factorization / Text analysis / / / / /  
Reference Info. IEICE Tech. Rep., vol. 119, no. 399, MI2019-99, pp. 151-154, Jan. 2020.
Paper # MI2019-99 
Date of Issue 2020-01-22 (MI) 
ISSN Online edition: ISSN 2432-6380
All rights are reserved and no part of this publication may be reproduced or transmitted in any form or by any means, electronic or mechanical, including photocopy, recording, or any information storage and retrieval system, without permission in writing from the publisher. Notwithstanding, instructors are permitted to photocopy isolated articles for noncommercial classroom use without fee. (License No.: 10GA0019/12GB0052/13GB0056/17GB0034/18GB0034)
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Conference Information
Committee MI  
Conference Date 2020-01-29 - 2020-01-30 
Place (in Japanese) (See Japanese page) 
Topics (in Japanese) (See Japanese page) 
Topics (in English) Medical Image Engineering, Analysis, Recognition, etc. 
Paper Information
Registration To MI 
Conference Code 2020-01-MI 
Language Japanese 
Title (in Japanese) (See Japanese page) 
Sub Title (in Japanese) (See Japanese page) 
Title (in English) Construction of Basis Vectors for Representation of Immunostaining Combination by Non-negative Matrix Decomposition 
Sub Title (in English)  
Keyword(1) Non-negative matrix decomposition  
Keyword(2) Boolean Matrix Factorization  
Keyword(3) Text analysis  
1st Author's Name Kaho Ko  
1st Author's Affiliation Nagoya Institute of Technology (NITech)
2nd Author's Name Noriaki Hashimoto  
2nd Author's Affiliation Nagoya Institute of Technology (NITech)
3rd Author's Name Tatsuya Yokota  
3rd Author's Affiliation Nagoya Institute of Technology (NITech)
4th Author's Name Masato Nakaguro  
4th Author's Affiliation Nagoya University Hospital (NUH)
5th Author's Name Kei Kohno  
5th Author's Affiliation Nagoya University Hospital (NUH)
6th Author's Name Shigeo Nakamura  
6th Author's Affiliation Nagoya University Hospital (NUH)
7th Author's Name Ichiro Takeuchi  
7th Author's Affiliation Nagoya Institute of Technology (NITech)
8th Author's Name Hidekata Hontani  
8th Author's Affiliation Nagoya Institute of Technology (NITech)
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Speaker Author-1 
Date Time 2020-01-30 10:00:00 
Presentation Time 10 minutes 
Registration for MI 
Paper # MI2019-99 
Volume (vol) vol.119 
Number (no) no.399 
Page pp.151-154 
Date of Issue 2020-01-22 (MI) 

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