Paper Abstract and Keywords |
Presentation |
2022-03-01 17:05
Construction of a fluorescence imaging system for electric field measurement in lipid bilayers Maki Komiya, Daiki Ando, Hironori Kageyama, Takaya Watanabe, Madoka Sato, Teng Ma (Tohoku Univ), Kensaku Kanomata, Fumihiko Hirose (Yamagata Univ), Ayumi Hirano-Iwata (Tohoku Univ) CPM2021-85 Link to ES Tech. Rep. Archives: CPM2021-85 |
Abstract |
(in Japanese) |
(See Japanese page) |
(in English) |
Ion channels, one of the transmembrane proteins, play important roles in biological activities. We have been developing analytical systems using artificial lipid bilayers to evaluate the mechanism of those ion channel proteins. In our recent study, we found that the electric field generated by the application of a voltage parallel to the lipid bilayer membrane affects the transmembrane current of the voltage-gated sodium ion channel (Nav1.5) embedded in the membrane. However, the mechanism of this phenomenon has not yet been revealed. Therefore, in this study, in order to clarify the mechanism, we had constructed a fluorescence imaging system for detecting the electric field in lipid bilayer membranes using voltage-sensitive dyes. |
Keyword |
(in Japanese) |
(See Japanese page) |
(in English) |
artificial cell membrane / ion channels / / / / / / |
Reference Info. |
IEICE Tech. Rep., vol. 121, no. 387, CPM2021-85, pp. 48-49, March 2022. |
Paper # |
CPM2021-85 |
Date of Issue |
2022-02-22 (CPM) |
ISSN |
Online edition: ISSN 2432-6380 |
Copyright and reproduction |
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CPM2021-85 Link to ES Tech. Rep. Archives: CPM2021-85 |
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